EFFICACY OF PROPHYLACTIC ONDANSETRON ON PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION DURING CAESARIAN DELIVERY; A RANDOMIZED CONTROLLED TRIAL
Dr Pampanna R
, Dr Anusha G Hiremath , Dr Pradnya Kothari
KEY WORDS: Caesarean section, ondansetron, hypotension, bezold‑jarisch reflex, ephedrine, phenylephrine.
BACKGROUND: Ondansetron a 5HT3 receptor blocker known to block BJR, can be beneficial in attenuating the maternal hypotension and bradycardia when injected before SAB. We aimed to study efficacy of prophylactic ondansetron 8mg iv on prevention of spinal anaesthesia induced hypotension during caesarian delivery. METHODS: Prospective, Randomized, Double-blinded, Controlled study was conducted on 64 parturient with a single foetus posted for Elective caesarean section under spinal anaesthesia who were divided into 2 groups, Group A received IV normal saline, 5 min before SAB and Group B received IV inj. Ondansetron 8 mg, 5 min before SAB. Both groups were co-loaded with 10ml/kg of RL over 20 min. Patient’s SBP,DBP,MAP,HR, ECG,SpO2 were monitored every minute for first 10 minutes after intrathecal injection, 2-minute intervals for the next 10 minutes and at 5-minute intervals thereafter need of vasopressors and adverse effects, outcomes in terms of APGAR score at 1minute and 5 minute. Umbilical arterial blood gas values were assessed. RESULTS: Intraoperative incidence of hypotension and hence the need for rescue vasopressors was significantly high (P < 0.001) in group A (90.63%). The Systolic Blood Pressure (SBP) remained to be lower in the group A compared to the Group B attaining statistical significance from the fourth minute after the administration of spinal anaesthesia till the twelfth minute. Mean DBP and MAP was decreased more in group A at different time intervals. 12(37.5%) and 5(15.6%) of the patients in Group A and B were presented with IONV. 16(50%) and 6(18.8%) were presented with PONV in Group A and Group B respectively with p value of 0.013. There was no difference in foetal outcome between the groups. CONCLUSION: Prophylactic use of 8 mg ondansetron IV is effective in reducing the incidence of spinal anaesthesia-induced hypotension, PONV, requirement of vasopressor in parturient undergoing elective caesarean section under spinal anesthesia.
"EFFICACY OF PROPHYLACTIC ONDANSETRON ON PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION DURING CAESARIAN DELIVERY; A RANDOMIZED CONTROLLED TRIAL", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 1, page no.413 - 421, January-2024, Available :https://ijsdr.org/papers/IJSDR2401061.pdf
Volume 9
Issue 1,
January-2024
Pages : 413 - 421
Paper Reg. ID: IJSDR_209864
Published Paper Id: IJSDR2401061
Downloads: 000347197
Research Area: Medical Science
Country: Bangalore, Karnataka, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
