AN OVERVIEW OF NANOSUSPENSION PREPARATION, CHARACTERIZATION, AND EVALUATION AS A STRATEGY FOR POORLY SOLUBLE DRUGS
Lavkush Santosh Jadhav
, Dr. Avinash H. Hosmani , Poonam B. Mane , Divyani D. Mane , Vishnu V. Mali
Nanosuspension, novel drug delivery, solubility enhancement, Surfactant.
Abstract :- The speed at which the drug development process is progressing is producing a number of novel drug candidates with good therapeutic efficacy but poor water solubility. Because of its unique physicochemical characteristics and submicron particle size, nanosuspension holds the potential to address numerous formulation and drug delivery challenges that are commonly linked to poorly soluble medicines in water and fat. To manufacture and scale-up nanosuspensions, conventional size reduction tools like media mills and high-pressure homogenizers as well as formulation strategies including solvent diffusion, emulsion-solvent evaporation, precipitation, and microemulsion procedures can be effectively used. For the successful manufacture and scaling-up of nanosuspensions, it is important to take into account two crucial factors: maintaining the stability in both the solid and solution states and resuspendability without aggregation. The versatility for surface modification and mucoadhesion for drug targeting, along with the notable improvement in bioavailability, have greatly broadened the application of this innovative formulation approach. Much research is now being done on the use of nanosuspensions in various drug delivery methods, including oral, ophthalmic, brain, topical, buccal, nasal, and transdermal routes. Receptor-mediated endocytosis in combination with oral drug delivery in nanosuspension has great promise for resolving most permeability-limited absorption and hepatic first-pass metabolism-related problems that negatively impact bioavailability. The development of enabling technologies, including nanosuspension, can address numerous formulation issues that currently plague protein and as well as peptide based formulation.
"AN OVERVIEW OF NANOSUSPENSION PREPARATION, CHARACTERIZATION, AND EVALUATION AS A STRATEGY FOR POORLY SOLUBLE DRUGS", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 1, page no.267 - 276, January-2024, Available :https://ijsdr.org/papers/IJSDR2401037.pdf
Volume 9
Issue 1,
January-2024
Pages : 267 - 276
Paper Reg. ID: IJSDR_209806
Published Paper Id: IJSDR2401037
Downloads: 000347251
Research Area: Pharmacy
Country: karad, Maharashtra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
