A Review of the pathogenesis of gouty arthritis

P. Selva Prasanthi , P. Manimekalai , K. Saranya , N. Dhivyadharshini , P. Saravanakumar

Gout, Hyperuricemia, HGPRT deficiency, Purine rich foods, URAT.

A common and severe form of inflammatory arthritis is gout. It occurs when monosodium urate crystals accumulate in tissues. Millions of outpatient visits are due to gouty arthritis each year, and the prevalence is rising. Hyperuricemia, or high serum uric acid levels, is the biological precursor to gout. The formation of uric acid crystals requires an increase in serum uric acid above a particular threshold. Since 99 percent of the molecules at physiologic pH are in the form of urate, the term "urate" is used in this sense rather than the more popular term, "uric acid". Considering that the uric acid saturation threshold in biological fluids is 7.0 mg/dl, uric acid concentrations in a healthy person’s blood are at 6.0 mg/dl. Local tissue macrophages are stimulated by monosodium urate crystals to release inflammatory cytokines, including IL1. The typical pathophysiologic characteristic of acute gout is the neutrophilic influx that is caused by these mediators along with complement. High protein intake and a variety of purine-rich meals have long been considered gout risk factors. OAT1 and OAT3 may be crucial in the etiology of hyperuricemia. Gout is a known result of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency. The primary mechanism for the reabsorption of urate in the human kidney is URAT-1, which belongs to the family of organic anion transporters. Gout and hyperuricemia are linked to URAT-1 gene mutations.

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"A Review of the pathogenesis of gouty arthritis", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 1, page no.133 - 141, January-2023, Available :https://ijsdr.org/papers/IJSDR2391022.pdf

Volume 8 Issue 1, January-2023

Pages : 133 - 141

Paper Reg. ID: IJSDR_203295

Published Paper Id: IJSDR2391022

Downloads: 000347234

Research Area: Pharmacy

Country: Namakkal, TamilNadu, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2391022

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2391022

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

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