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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A Review of the pathogenesis of gouty arthritis |
| Authors Name: | P. Selva Prasanthi , P. Manimekalai , K. Saranya , N. Dhivyadharshini , P. Saravanakumar |
| Unique Id: | IJSDR2391022 |
| Published In: | Volume 8 Issue 1, January-2023 |
| Abstract: | A common and severe form of inflammatory arthritis is gout. It occurs when monosodium urate crystals accumulate in tissues. Millions of outpatient visits are due to gouty arthritis each year, and the prevalence is rising. Hyperuricemia, or high serum uric acid levels, is the biological precursor to gout. The formation of uric acid crystals requires an increase in serum uric acid above a particular threshold. Since 99 percent of the molecules at physiologic pH are in the form of urate, the term "urate" is used in this sense rather than the more popular term, "uric acid". Considering that the uric acid saturation threshold in biological fluids is 7.0 mg/dl, uric acid concentrations in a healthy person’s blood are at 6.0 mg/dl. Local tissue macrophages are stimulated by monosodium urate crystals to release inflammatory cytokines, including IL1. The typical pathophysiologic characteristic of acute gout is the neutrophilic influx that is caused by these mediators along with complement. High protein intake and a variety of purine-rich meals have long been considered gout risk factors. OAT1 and OAT3 may be crucial in the etiology of hyperuricemia. Gout is a known result of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency. The primary mechanism for the reabsorption of urate in the human kidney is URAT-1, which belongs to the family of organic anion transporters. Gout and hyperuricemia are linked to URAT-1 gene mutations. |
| Keywords: | Gout, Hyperuricemia, HGPRT deficiency, Purine rich foods, URAT. |
| Cite Article: | "A Review of the pathogenesis of gouty arthritis", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 1, page no.133 - 141, January-2023, Available :http://www.ijsdr.org/papers/IJSDR2391022.pdf |
| Downloads: | 000337061 |
| Publication Details: | Published Paper ID: IJSDR2391022 Registration ID:203295 Published In: Volume 8 Issue 1, January-2023 DOI (Digital Object Identifier): Page No: 133 - 141 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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