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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Various Pharmacological role of NMDA`s receptors in the various Neuro-disorder and Peripheral organs |
| Authors Name: | Vinoth Kumar R , Sivakumar G , Santhosh Kumar E , Monica K , Mathiazhagan G M |
| Unique Id: | IJSDR2305318 |
| Published In: | Volume 8 Issue 5, May-2023 |
| Abstract: | NMDA receptors are ionotropic receptors mediating glutamatergic neurotransmission and play a role in several basic functions in the central nervous system, from regulating neurodevelopment and synaptic plasticity, learning and memory formation, cognitive processes, rhythm generation necessary for locomotor activity and breathing, and excitotoxicity. Due to their complex involvement in the above processes, NMDA receptors have been established to play a role in the etiopathology of several neuropsychiatric disorders such as ischaemia and traumatic brain injury, neurodegenerative disorders, pain syndromes, addiction, affective disorders and such neurodevelopmental disorders as autism or schizophrenia. Besides, the receptors have also been found to present extensively in peripheral organs, such as lungs, kidneys, heart, and pancreas. Under various pathological conditions, peripheral NMDARs are upregulated and excessively activated, initiating calcium influx and intracellular calcium overloading. Subsequently, mitochondrial dysfunction, oxidative stress, and proinflammatory signalling pathway activation ultimately aggravate tissue damage and organ dysfunction. In addition, excessive activation of NMDARs also directly initiates mitochondrial apoptosis in many organs. Here, we discuss pathophysiological roles of NMDARs in cardiovascular system, lungs, kidneys, and pancreas. |
| Keywords: | Arrhythmia, Diabetic Nephropathy, Huntington’s Disease, Pancreatic Tumours |
| Cite Article: | "Various Pharmacological role of NMDA`s receptors in the various Neuro-disorder and Peripheral organs", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.2011 - 2019, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305318.pdf |
| Downloads: | 000337074 |
| Publication Details: | Published Paper ID: IJSDR2305318 Registration ID:206305 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: 2011 - 2019 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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