|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.15 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Formulation And Evaluation Of Floating Tablets |
| Authors Name: | Pranav Dilip Kolte , Dr.Prasik B. Dudhe , Dr. Kailash R. Biyani , Dr. S. C. Kale |
| Unique Id: | IJSDR2305254 |
| Published In: | Volume 8 Issue 5, May-2023 |
| Abstract: | The drug delivery system aims to provide a therapeutic amount of drug to the desired site in the body and maintain the desired plasma concentration of the drug for a particular period of time. Lamivudine, an anti-viral drug, choice in the treatment of HIV has been chosen as a model drug in the formulation of controlled drug delivery systems for the present work. Various studies reported the absolute bioavailability of Lamivudine (86%) when administrate orally with a half-life of 4-6 hrs. A microparticulate floating drug delivery system was planned for Lamivudine as such a system release for a prolonged period of time and the drug would be available in the dissolved form. This would lead to improvement in the bioavailability of the drug. In this way, it stands an advantage over conventional dosage forms. Floating tablet formulations were prepared using HPMCK4M and Xanthan Gum. The prepared floating tables were characterized by their pre- and post-compression parameters. Almost all the formulations showed fairly acceptable values for all the parameters evaluated. Further, the analysis of the release mechanism was carried out by fitting the drug diffusion data to various kinetic equations. The overall curve fitting into various mathematical models was found to be average and best fitted into the zero-order kinetic model. A stability study was conducted for the prepared batch of F4-selected formulations for 60 days. There was no significant change in the drug entrapment and in-vitro release study of the floating tablet. |
| Keywords: | Antiviral, Floating tablet, Lamivudine |
| Cite Article: | "Formulation And Evaluation Of Floating Tablets", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.1613 - 1617, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305254.pdf |
| Downloads: | 000223171 |
| Publication Details: | Published Paper ID: IJSDR2305254 Registration ID:206538 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: 1613 - 1617 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2023 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn