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Issue: May 2023

Volume 8 | Issue 5

Impact factor: 8.15

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Paper Title: Pharmacological Evaluation of Solanum Nigrum Leaves extract for its Memory enhancing activity
Authors Name: Ankita Raghuraj Pandey , Dr. Rajesh Mandade , Prof. R. K. Kadam
Unique Id: IJSDR2305214
Published In: Volume 8 Issue 5, May-2023
Abstract: In the traditional system of medicine, the Leaves and berries of Solanum Nigrum  have been employed clinically for centuries for their anti-inflammatory, antiulcer, antimicrobial and anxiolytic activities. The present study was undertaken to investigate the effects of Solanum Nigrum (popularly known as Blackberry) on learning and memory in mice. Elevated plus-maze and Water Morris maze were employed to test learning and memory. Two doses (100 and 200mg/kg p.o.) of Methanolic extract of Solanum Nigrum Leaves were administered for 7 successive days in separate groups of animals. The dose of 200 mg/kg of the methanolic extract of Blackberry significantly improved learning and memory of mice. Furthermore, this dose significantly reversed the amnesia induced by Piracetam (200 mg/kg i.p.) and scopolamine (0.1 mg/kg i.p.). Anti-inflammatory and antioxidant properties of Blackberry may be contributing favourably to the memory enhancement effect. Since scopolamine-induced amnesia was reversed by Blackberry, it is possible that the beneficial effect on learning and memory was due to facilitation of cholinergic-transmission in mouse brain. However, further studies are necessitated to identify the exact mechanism of action. In the present investigation, Solanum Nigrum has shown promise as a memory enhancing agent in all the laboratory models employed
Keywords: Solanum Nigrum, Scopolamine, Piracetam, Memory Enhancement, amnesia
Cite Article: "Pharmacological Evaluation of Solanum Nigrum Leaves extract for its Memory enhancing activity", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.1342 - 1348, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305214.pdf
Downloads: 000222060
Publication Details: Published Paper ID: IJSDR2305214
Registration ID:206542
Published In: Volume 8 Issue 5, May-2023
DOI (Digital Object Identifier):
Page No: 1342 - 1348
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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