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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Pharmacological Evaluation of Solanum Nigrum Leaves extract for its Memory enhancing activity |
| Authors Name: | Ankita Raghuraj Pandey , Dr. Rajesh Mandade , Prof. R. K. Kadam |
| Unique Id: | IJSDR2305214 |
| Published In: | Volume 8 Issue 5, May-2023 |
| Abstract: | In the traditional system of medicine, the Leaves and berries of Solanum Nigrum have been employed clinically for centuries for their anti-inflammatory, antiulcer, antimicrobial and anxiolytic activities. The present study was undertaken to investigate the effects of Solanum Nigrum (popularly known as Blackberry) on learning and memory in mice. Elevated plus-maze and Water Morris maze were employed to test learning and memory. Two doses (100 and 200mg/kg p.o.) of Methanolic extract of Solanum Nigrum Leaves were administered for 7 successive days in separate groups of animals. The dose of 200 mg/kg of the methanolic extract of Blackberry significantly improved learning and memory of mice. Furthermore, this dose significantly reversed the amnesia induced by Piracetam (200 mg/kg i.p.) and scopolamine (0.1 mg/kg i.p.). Anti-inflammatory and antioxidant properties of Blackberry may be contributing favourably to the memory enhancement effect. Since scopolamine-induced amnesia was reversed by Blackberry, it is possible that the beneficial effect on learning and memory was due to facilitation of cholinergic-transmission in mouse brain. However, further studies are necessitated to identify the exact mechanism of action. In the present investigation, Solanum Nigrum has shown promise as a memory enhancing agent in all the laboratory models employed |
| Keywords: | Solanum Nigrum, Scopolamine, Piracetam, Memory Enhancement, amnesia |
| Cite Article: | "Pharmacological Evaluation of Solanum Nigrum Leaves extract for its Memory enhancing activity", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.1342 - 1348, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305214.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2305214 Registration ID:206542 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: 1342 - 1348 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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