|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | CCKAR expression in the neoplastic and non-neoplastic gall bladder lesion-A comparative study |
| Authors Name: | DR PANKHUDI GUPTA , DR SRISHTI SONI , DR SAJAG KUMAR GUPTA , DR DHRITI SAXENA |
| Unique Id: | IJSDR2305062 |
| Published In: | Volume 8 Issue 5, May-2023 |
| Abstract: | Gall bladder carcinoma is considered as the fifth most common gastro-intestinal neoplasm and most common biliary tract malignancy in world. Spread of gall bladder carcinoma (GBC) to the liver parenchyma and the adjacent internal organs is due to lack of serosa in gall bladder wall and cholecystic veins draining into liver portal vein. Also, Incidence of Gall bladder cancer shows striking geographical predilections, with highest figures found in India and Chile and relatively low level seen in many western countries. Regulatory peptide receptors have now attracted interest of oncologists as a new promising approach for cancer pathology, imaging and therapy. CCKAR encodes a G-protein-coupled receptor that binds cholecystokinin (CCK) family of peptide hormones and also is a major physiological mediator of pancreatic growth and enzyme secretion, smooth muscle contraction of the gallbladder and stomach. Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR), its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has been less evaluated. The aim of the study is to compare the expression of CCKAR in neoplastic and non-neoplastic lesions of gall bladder. This case-control study included 100 samples: 50 from GBC and 50 from Chronic cholecystitis. The expression of CCKAR was analysed by immunohistochemistry. There was a significant difference in CCKAR expression between chronic cholecystitis and GBC. So, it has future prognostic and therapeutic implications in the management of GBC |
| Keywords: | GALL BLADDER CARCINOMA,CCKAR,NEOPLASM,CANCER |
| Cite Article: | "CCKAR expression in the neoplastic and non-neoplastic gall bladder lesion-A comparative study ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.400 - 403, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305062.pdf |
| Downloads: | 000337071 |
| Publication Details: | Published Paper ID: IJSDR2305062 Registration ID:206131 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: 400 - 403 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn