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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Issue: May 2023

Volume 8 | Issue 5

Impact factor: 8.15

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Paper Title: CCKAR expression in the neoplastic and non-neoplastic gall bladder lesion-A comparative study
Authors Name: DR PANKHUDI GUPTA , Dr Sajag Kumar gupta
Unique Id: IJSDR2305062
Published In: Volume 8 Issue 5, May-2023
Abstract: Gall bladder carcinoma is considered as the fifth most common gastro-intestinal neoplasm and most common biliary tract malignancy in world. Spread of gall bladder carcinoma (GBC) to the liver parenchyma and the adjacent internal organs is due to lack of serosa in gall bladder wall and cholecystic veins draining into liver portal vein. Also, Incidence of Gall bladder cancer shows striking geographical predilections, with highest figures found in India and Chile and relatively low level seen in many western countries. Regulatory peptide receptors have now attracted interest of oncologists as a new promising approach for cancer pathology, imaging and therapy. CCKAR encodes a G-protein-coupled receptor that binds cholecystokinin (CCK) family of peptide hormones and also is a major physiological mediator of pancreatic growth and enzyme secretion, smooth muscle contraction of the gallbladder and stomach. Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR), its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has been less evaluated. The aim of the study is to compare the expression of CCKAR in neoplastic and non-neoplastic lesions of gall bladder. This case-control study included 100 samples: 50 from GBC and 50 from Chronic cholecystitis. The expression of CCKAR was analysed by immunohistochemistry. There was a significant difference in CCKAR expression between chronic cholecystitis and GBC. So, it has future prognostic and therapeutic implications in the management of GBC
Cite Article: "CCKAR expression in the neoplastic and non-neoplastic gall bladder lesion-A comparative study ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.400 - 403, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305062.pdf
Downloads: 000222060
Publication Details: Published Paper ID: IJSDR2305062
Registration ID:206131
Published In: Volume 8 Issue 5, May-2023
DOI (Digital Object Identifier):
Page No: 400 - 403
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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