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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Treatment Outcome Of Drug Resistant Tuberculosis After 6 Months Of Bedaquiline Containing Anti-Tubercular Treatment |
| Authors Name: | Anil Kumar Dansena , R. K. Panda , Roshan Singh Rathore |
| Unique Id: | IJSDR2304305 |
| Published In: | Volume 8 Issue 4, April-2023 |
| Abstract: | Background & Method: The aim is to study the treatment outcome of drug resistant tuberculosis after 6 months of bedaquiline containing anti-tubercular treatment. This study was conducted on patients enrolled under Nodal drug resistant tuberculosis centre or attending OPD in Department of Respiratory Medicine at Pt. J. N. M. Medical college, Raipur (C.G.) during study period. The institute provides NTEP, Nodal DR-TB centre and PMDT services, tertiary level of respiratory and critical care services to the patients. Inclusion/exclusion criteria and treatment initiation/follow up was done under programmatic guidelines. This study was performed primarily focusing on clinical profile and drug resistance pattern of patients to determine the treatment outcome after 6 months of bedaquiline-containing anti-tubercular regimen in DR-TB patients. Result: Among all enrolled patients (n=38) 27 (71.1%) were undernourished, 10 (26.3%) were normal and 1(2.6%) patient was pre-obese. Mean BMI (+ standard deviation) was 16.71 (+ 2.74) Kg/m2. Out of 38 patients, 21(55.3%) patients were detected RIF Resistance by NAAT, 27(71.1%) patients had mutation in Rpo-B gene, 21(55.3%) patients had mutation in Kat G gene, 5(13.2%) patients had mutation in Inh A, 14(36.8%) patients had mutation in Gyr A, 0(0.0%) patients had mutation in Gyr B & eis genes, and 2(5.3%) patients had mutation in rrs gene. The rate of sputum smear and culture conversion at 3rd month were 83.33% and 86.1% and at 6th months were 88.8% and 88.9% respectively, 3 patients were died during the course of treatment and 2 patients were lost to follow-up. Conclusion: This study concluded that bedaquiline is one of the most important component of the antitubercular regimen for drug resistant tuberculosis. It makes the anti-tubercular regimen more effective which leads to increased chance of sputum smear and culture conversion among DRTB patients. Bedaquiline is tolerated by most of the patient if started after following the programmatic management of drug resistant tuberculosis guidelines accordingly. Nutrition plays an important role in compliance of the patients. Higher rate of sputum smear and culture conversion helps not only in better cure of the patient but also helps in curtailing the spread of infection. |
| Keywords: | drug, resistant, tuberculosis, bedaquiline & anti-tubercular. |
| Cite Article: | "Treatment Outcome Of Drug Resistant Tuberculosis After 6 Months Of Bedaquiline Containing Anti-Tubercular Treatment", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 4, page no.1972 - 1975, April-2023, Available :http://www.ijsdr.org/papers/IJSDR2304305.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2304305 Registration ID:205577 Published In: Volume 8 Issue 4, April-2023 DOI (Digital Object Identifier): Page No: 1972 - 1975 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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