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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Antifertility studies of various chromatographic fractions of neem seed oil i female albino rabbits:A histological approach |
| Authors Name: | Vijeyata vyas , ASHOK PUROHIT |
| Unique Id: | IJSDR2304232 |
| Published In: | Volume 8 Issue 4, April-2023 |
| Abstract: | ABSTRACT Background Preparation of plant or parts of them were widely used in popular medicine since ancient times and till today the use of phyto medicines is wide spread in most of the world’s population. Among diverse herbal treasure Azardichta indica is a highly esteemed tree with several beneficial properties and applications. The aim of present study was to observe antifertility efficacy of Neem seed oil and its active Fractions on female albino rabbits with special reference to its histological aspect. Methods Animals were given neem seed oil alone and its fractions I, II, III, IV, V and VI to female albino rabbits between 10 to 500 mg/body weight orally for 28 days.The histology of ovary uterus, vagina and vital organ such as liver kidney and heart were done through standard method and histometry of ovary uterus and vagina was done through camera lucida. Result In present investigation no adverse effect reported on histoarchitecture of vital organs such as liver, kidney, heart t but in histological examination of ovary showed arrest of oogenesis at various stages of follicles development in Neem seed oil alone and its fraction IV and V treated group.. The developing follicles undergo atresia with the derangement of the granulosa cells and the nuclear pykonsis in fraction IV and V. Similarly they affect the uterus drastically. Histologically uterus showed a reduction in the height of glandular epithelial and endothelial wall showed smoothness and reduction. The thickness of vaginal epithelium reduces to a few cell layers. Conclusion The above result confirms the antiestrogenic nature of Neem seed oil and its Fraction IV and V. The vital organ histology confirms no toxic effect by plant products. The histometry of ovary follicle, thickness of vaginal epithelium and uterus epithelium reflects antiestrogenic nature of neem seed oil alone and its fraction IV and V. Thus the above finding suggest the fraction IV and V and neem seed oil alone possesses some phytochemical which inhibits oogenesis and cause infertility in rabbits .Further experimentation is in progresses . KEY WORDS Antifertility, Antiestrogenic, Ovarian histoarchitecture. |
| Keywords: | KEY WORDS Antifertility, Antiestrogenic, Ovarian histoarchitecture. |
| Cite Article: | "Antifertility studies of various chromatographic fractions of neem seed oil i female albino rabbits:A histological approach", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 4, page no.1441 - 1447, April-2023, Available :http://www.ijsdr.org/papers/IJSDR2304232.pdf |
| Downloads: | 000337212 |
| Publication Details: | Published Paper ID: IJSDR2304232 Registration ID:204876 Published In: Volume 8 Issue 4, April-2023 DOI (Digital Object Identifier): Page No: 1441 - 1447 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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