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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

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Issue: April 2024

Volume 9 | Issue 4

Impact factor: 8.15

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Paper Title:	Validation of Stability Indicating RP-HPLC method for phloroglucinol in pharmaceutical Oral Solid Dosage Form
Authors Name:	Ezhilarasi Azhagesan , Dr. Shantaram Nangude , Dr. Raja Subburayalu , V. Vijay , Dr. K. Devi
Unique Id:	IJSDR2304070
Published In:	Volume 8 Issue 4, April-2023
Abstract:	A Simple, accurate and precise reverse phase high performance liquid chromatography (RP-HPLC) method for the Phloroglucinol (PHLO) in marketed formulation was developed. The determination was carried out on Inertsil ODS 3V C18 (250 x 4.6 mm, 5 µm) column using a mobile phase buffer and acetonitrile in the ratio of 90: 10 by isocratic mode. The flow rate was 1.0 ml/min with detection at 265 nm. The retention time for phloroglucinol was 3.8 min. Phloroglucinol showed a linear response in the concentration range of 256 to 384 µg/ml. The correlation co-efficient (' r ' value) for PHLO was 0.999. The percentage recoveries obtained for phloroglucinol ranges from 100.2% to 101.3%. The developed method was validated as per ICH Q2 R1 guidelines and was successfully applied for estimation of phloroglucinol in Synthetic Mixture.
Keywords:	RP-HPLC method, Phloroglucinol, ICH.
Cite Article:	"Validation of Stability Indicating RP-HPLC method for phloroglucinol in pharmaceutical Oral Solid Dosage Form ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 4, page no.371 - 376, April-2023, Available :http://www.ijsdr.org/papers/IJSDR2304070.pdf
Downloads:	000337077
Publication Details:	Published Paper ID: IJSDR2304070 Registration ID:204919 Published In: Volume 8 Issue 4, April-2023 DOI (Digital Object Identifier): Page No: 371 - 376 Publisher: IJSDR \| www.ijsdr.org ISSN Number: 2455-2631

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