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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Cooperative study of the side effect profiles of sublingual misoprostol and rectal misoprostol used in prevention of postpartum haemorrhage in Enugu Nigeria |
| Authors Name: | Ezenwaeze Malachy Nwaeze , Sylvester Nweze Onuegbunam , Leo Clinton Chukwu |
| Unique Id: | IJSDR2304004 |
| Published In: | Volume 8 Issue 4, April-2023 |
| Abstract: | ABSTRACT Background: Misoprostol has uterotonic properties and can be administered rectally or sublingually in prevention/treatment of post-partum haemorrhage. There is a need to investigate the misoprostol side effects associated with the different routes. Objective: To compare the side effect profile, blood loss and preference of sub lingual misoprostol with rectal misoprostol use in preventing primary post-partum haemorrhage in women with risk factor(s) to PPH. Methodology: This is a prospective comparative study that involved 200 participants who were randomized to two groups by 1:1 computer-based randomization (group A & group B). Each participant in group A received 600mcg sub lingual misoprostol plus rectal placebo and participants in group B received 600mcg rectal misoprostol plus sub lingual placebo after delivery. The delivery mat already in use and soaked with liquor was removed once delivery was imminent and a new pre-weighed mat replaced under the patients buttocks and also a pre-weighed sanitary pad placed in her vulva to collect all the blood loss, in addition, drug side effect(s), preferred route of misoprostol administration were assessed and findings documented in the proforma. Blood loss throughout a period of 24 hours after delivery was measured by gravimetric method. Weight gain from the sanitary pad/ delivery mat was calculated as 1g = 1ml. The sanitary pad/mat was weighed in triplicate and the mean of the three weights entered into the database. The difference was the amount of blood loss assuming 1g to be equivalent to 1ml of blood. Result:. Greater number of research participants in sub lingual group (58%) had drug side effect compared with rectal group of participants (18%); P-value = 0.001. This was statistically significant, although well tolerated. The sub lingual group exhibited higher shivering (48% versus 12%; p < 0.001), vomiting (6.0% versus 0.0%; p < 0.001) and fever,( 4.0% versus 0.0%; p < 0.001) while the rectal route group showed higher cases of diarrhoea (6.6%versus 0.0%; p < 0.001). The median 24hour post-partum blood loss was less in sub lingual group compared with rectal group (110ml vs 170ml; P=0.001). Almost all the participants in the study (99%) preferred sub lingual route of misoprostol administration even with its higher but well tolerable side effects. Conclusion: It is concluded that sub-lingual route of misoprostol administration is associated with higher but well tolerated side effects and is also the preferred route for misoprostol administration. |
| Keywords: | Side Effects, Misoprostol, Sub-lingual, Rectal, Post-partum haemorrhage |
| Cite Article: | "Cooperative study of the side effect profiles of sublingual misoprostol and rectal misoprostol used in prevention of postpartum haemorrhage in Enugu Nigeria", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 4, page no.16 - 21, April-2023, Available :http://www.ijsdr.org/papers/IJSDR2304004.pdf |
| Downloads: | 000337071 |
| Publication Details: | Published Paper ID: IJSDR2304004 Registration ID:204743 Published In: Volume 8 Issue 4, April-2023 DOI (Digital Object Identifier): Page No: 16 - 21 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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