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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Induction and Prognosis of Rheumatoid Arthritis: Biological Determination by Denaturation of Proteinase Technique and Antiproteinase Assay |
| Authors Name: | Mr. Jithin Mathew |
| Unique Id: | IJSDR2302080 |
| Published In: | Volume 8 Issue 2, February-2023 |
| Abstract: | Statins are the drugs used for the treatment of hyperlipidemia along with cholesterol lowering activity. These drugs may eventually leads to dysregulation of immune response. The primary objective of the present study focused on the induction of autoimmunity. The biological studies performed are denaturation of proteins and Inhibition of proteases assay. The result showed that Pitavastatin and Lovastatin administration during the active range of 62.5 – 500µg/ml indicated highest inhibitory profile on denaturation of proteins. Statins also exhibited maximum protease inhibitory activity during the percentage range of 12.28- 64.4%. The recent evidence obtained from the study indicated both statins had little effect on Rheumatoid arthritis. The study claimed that both Pitavastatin and Lovastatin use promoted higher chance for developing Rheumatoid arthritis. |
| Keywords: | Pitavastatin, Lovastatin, Proteinase denaturation, Proteinase Inhibtion, Autoimmunity |
| Cite Article: | "Induction and Prognosis of Rheumatoid Arthritis: Biological Determination by Denaturation of Proteinase Technique and Antiproteinase Assay", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 2, page no.463 - 467, February-2023, Available :http://www.ijsdr.org/papers/IJSDR2302080.pdf |
| Downloads: | 000337212 |
| Publication Details: | Published Paper ID: IJSDR2302080 Registration ID:203963 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: 463 - 467 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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