INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Synthesis and formulation of curcumin nanoparticles
Authors Name:
D. Rama Brahma Reddy
, K. Malleswari , A. Dileep kumar Reddy
Unique Id:
IJSDR2302008
Published In:
Volume 8 Issue 2, February-2023
Abstract:
Nanoparticles comprised of carboxymethyl cellulose acetate butyrate (CMCAB) complexed with the poorly soluble drug Curcumin was produced by a rapid precipitation process and the formulation process and properties of nanoparticles were investigated. Two different particle synthesis methods were explored – a conventional precipitation method and a rapid precipitation in a multi-inlet vortex mixer (MIVM). The particles were processed by rotavapor followed by freeze drying or hot air oven drying. Particle diameters as measured by dynamic light scattering were dependent on the synthesis method used. The conventional precipitation method did not show desired particle size distribution. Whereas, particles prepared by the mixer showed well defined particle size ~ 130-300 nm before and after freeze drying respectively with lower polydispersity indices. Fourier-transform infrared spectroscopy showed chemical stability and intactness of entrapped drug in the nanoparticles. Differential Scanning Calorimetry showed that the drug was in amorphous state in the polymer matrix.
Keywords:
Curcumin; Polymer Drug Nanoparticles
Cite Article:
"Synthesis and formulation of curcumin nanoparticles", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 2, page no.42 - 47, February-2023, Available :http://www.ijsdr.org/papers/IJSDR2302008.pdf
Downloads:
000336256
Publication Details:
Published Paper ID: IJSDR2302008
Registration ID:203815
Published In: Volume 8 Issue 2, February-2023
DOI (Digital Object Identifier):
Page No: 42 - 47
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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