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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Design, development and optimization of multiple-unit buoyant beads containing pioglitazone. |
| Authors Name: | Jadupati Malakar , Mithun Bhowmick |
| Unique Id: | IJSDR2302002 |
| Published In: | Volume 8 Issue 2, February-2023 |
| Abstract: | In the current work, formulation optimization of multiple-unit pioglitazone-loaded buoyant beads was using various polymers like low methoxyl pectin (methoxyl content less than 7%), Poloxamer 407 and magnesium stearate as low density materials as independent variables and their effects on drug entrapment efficiency (DEE, %) and cumulative drug release after 8 h (R8h, %) as responses were analyzed after performing a full 23 factorial design. The optimized formula for the preparation of buoyant beads containing Pioglitazone was found 749.98 mg low methoxyl pectin, 345.43 mg Poloxamer 407 and 166.33 mg magnesium stearate. The average diameter, density values, and DEE (%) of these dried beads containing Pioglitazone ranged from 1.67 ± 0.05 to 1.86 ± 0.07 mm, 0.901 ± 0.08 to 0.984 ± 0.09 gm/cm3 and 66.21 ± 2.72 to 75.43 ± 2.15%. These optimized formulations of beads were characterized by scanning electron microscopy and FTIR spectroscopy. These formulated beads containing pioglitazone were showed buoyancy as well as sustained release over 8 h, in vitro. |
| Keywords: | Keywords: Pioglitazone; Buoyant beads; Multiple-unit; Sustained release; 23 factorial designs. |
| Cite Article: | "Design, development and optimization of multiple-unit buoyant beads containing pioglitazone.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 2, page no.4 - 16, February-2023, Available :http://www.ijsdr.org/papers/IJSDR2302002.pdf |
| Downloads: | 000337069 |
| Publication Details: | Published Paper ID: IJSDR2302002 Registration ID:203674 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: 4 - 16 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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