BURDEN OF DENGUE AND CHIKUNGUNYA CO-INFECTION IN PATIENT ATTENDING TERTIARY CARE HOSPITAL,PUNE
Dr. Neha Bagade
, Dr.Suvarana Joshi , Dr.Rajesh Karyakarte
Dengue,Chikungunya,Dengue-chikungunya co-infection,Arboviral infection
Introduction: Arthropod-borne viral infections are a major public health problem in the tropical and subtropical regions across the world including India. Amongst them Dengue and Chikungunya pose a significant threat and share a common insect vector. In last few decades, India has experienced several outbreaks of dengue and chikungunya. Early clinical manifestations of these arboviral infections are similar and difficult to differentiate. Further, there are recent reports of co-infection with dengue and chikungunya viruses. It is therefore essential to know whether there is a co-infection with both viruses. A detailed review of literature revealed only a few studies reporting dual infection. The present study was undertaken to find out the burden of co-infection with dengue and chikungunya viruses in and around Pune. Objectives: To find out the prevalence of dengue and chikungunya virus co-infection in cases of febrile illness. Materials and Method: A total of 4145 samples from clinically suspected cases of viral febrile illness were studied over a period of one year(May 2018-May 2019).Each sample was tested for both Dengue and Chikungunya IgM antibodies. Further, all samples were tested for Dengue NS-1 antigen. For detection of IgM antibodies, IgM capture ELISA (MAC-ELISA) test was done using kits manufactured by National Institute of Virology, Pune. NS-1 antigen detection was achieved with ELISA test by kits manufactured by J Mitra Pvt. Ltd. Results: Out of 4145 samples tested for both Dengue and Chikungunya infection, 1359 (32.78%) showed evidence of infection. A total of 718 samples (52.83%) were positive for Dengue infection alone, while 588 samples (43.26%) were positive for only chikungunya. There were a total of 53 samples (3.89%) that showed presence of IgM antibodies against both Dengue and Chikungunya viruses, indicating co-infection. Conclusions: The present study highlights the importance of laboratory support for diagnosis of co-infection of Dengue and Chikungunya. Clinically suspected cases of viral febrile illness should be tested for both of these viral infections in endemic areas like India as this will also help in knowing the true burden of dengue and chikungunya co-infection. Further, timely and appropriate management can assist in the prediction and control of outbreaks with both viruses.
"BURDEN OF DENGUE AND CHIKUNGUNYA CO-INFECTION IN PATIENT ATTENDING TERTIARY CARE HOSPITAL,PUNE", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 1, page no.657 - 661, January-2023, Available :https://ijsdr.org/papers/IJSDR2301109.pdf
Volume 8
Issue 1,
January-2023
Pages : 657 - 661
Paper Reg. ID: IJSDR_203618
Published Paper Id: IJSDR2301109
Downloads: 000347331
Research Area: Health Science
Country: Amravati, Maharashtra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
