IN-SILICO STUDY NOVEL 5HT2A ANTAGONIST FOR ANTIHYPERTENSIVE ACTION

Jitendra Bhalavi , Dr. Dinesh Kawade , Datta Avhad , Abhinav Bais , Vaibhav Mohare

Antihypertension, 5HT2a receptor, Pyrazine, Vasoconstriction

Hypertension occurs when blood pressure gets elevated to 130-139 mmHg(systolic) and 80-89 mmHg(diastolic). The cause of hypertension is the generation of angiotensin II (octapeptide) from angiotensin I (decapeptide) by an angiotensin-converting enzyme (ACE). This angiotensin II is further converted into angiotensin III by an action of an aminopeptidase. This angiotensin III is 2-10 times less potent than angiotensin II which is produced by an action of an angiotensin-converting enzyme (ACE). So, for the treatment of hypertension, it is necessary to target the angiotensin-converting enzyme (ACE). 1.28 billion adults aged 30-79 years worldwide have hypertension. 5ht2a receptor inhibitor are the drug which inhibit the all the actions of 5ht2a receptors. 5ht2a receptors is the most widely expressed postjunctional 5HT receptors located on vascular and visceral smooth muscle,platelates and cerebral neurones especially prefrontal cortex. It mediates most of the direct actions of 5-HT like vasoconstriction, intestinal, uterine and bronchial contraction platelate aggregation and activation of cerebral neurones.the drugs which inhibit 5-HT2a receptors give vasodilation which can be used in hypertension. The ligand i.e. 4-(5H-Dibenzo[a,d]cycloheptene-5-ylidene)-1,4-pyrazine are bind to the maximum amino acids of 5HT2A receptors and shows an interaction with 5HT2a receptor (PDB ID:OAJ). This novel ligand shows Stable binding affinity. This study concluded that, novel ligand 4-(5H-Dibenzo[a,d]cycloheptene-5-ylidene)-1,4-pyrazine might be helpful for the treatment of Hypertension

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"IN-SILICO STUDY NOVEL 5HT2A ANTAGONIST FOR ANTIHYPERTENSIVE ACTION", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 1, page no.616 - 627, January-2023, Available :https://ijsdr.org/papers/IJSDR2301103.pdf

Volume 8 Issue 1, January-2023

Pages : 616 - 627

Paper Reg. ID: IJSDR_203599

Published Paper Id: IJSDR2301103

Downloads: 000347214

Research Area: Computer Aided Structural Analysis & Design 

Country: Nagpur, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2301103

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2301103

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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