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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | IN-SILICO STUDY NOVEL 5HT2A ANTAGONIST FOR ANTIHYPERTENSIVE ACTION |
| Authors Name: | Jitendra Bhalavi , Dr. Dinesh Kawade , Datta Avhad , Abhinav Bais , Vaibhav Mohare |
| Unique Id: | IJSDR2301103 |
| Published In: | Volume 8 Issue 1, January-2023 |
| Abstract: | Hypertension occurs when blood pressure gets elevated to 130-139 mmHg(systolic) and 80-89 mmHg(diastolic). The cause of hypertension is the generation of angiotensin II (octapeptide) from angiotensin I (decapeptide) by an angiotensin-converting enzyme (ACE). This angiotensin II is further converted into angiotensin III by an action of an aminopeptidase. This angiotensin III is 2-10 times less potent than angiotensin II which is produced by an action of an angiotensin-converting enzyme (ACE). So, for the treatment of hypertension, it is necessary to target the angiotensin-converting enzyme (ACE). 1.28 billion adults aged 30-79 years worldwide have hypertension. 5ht2a receptor inhibitor are the drug which inhibit the all the actions of 5ht2a receptors. 5ht2a receptors is the most widely expressed postjunctional 5HT receptors located on vascular and visceral smooth muscle,platelates and cerebral neurones especially prefrontal cortex. It mediates most of the direct actions of 5-HT like vasoconstriction, intestinal, uterine and bronchial contraction platelate aggregation and activation of cerebral neurones.the drugs which inhibit 5-HT2a receptors give vasodilation which can be used in hypertension. The ligand i.e. 4-(5H-Dibenzo[a,d]cycloheptene-5-ylidene)-1,4-pyrazine are bind to the maximum amino acids of 5HT2A receptors and shows an interaction with 5HT2a receptor (PDB ID:OAJ). This novel ligand shows Stable binding affinity. This study concluded that, novel ligand 4-(5H-Dibenzo[a,d]cycloheptene-5-ylidene)-1,4-pyrazine might be helpful for the treatment of Hypertension |
| Keywords: | Antihypertension, 5HT2a receptor, Pyrazine, Vasoconstriction |
| Cite Article: | "IN-SILICO STUDY NOVEL 5HT2A ANTAGONIST FOR ANTIHYPERTENSIVE ACTION", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 1, page no.616 - 627, January-2023, Available :http://www.ijsdr.org/papers/IJSDR2301103.pdf |
| Downloads: | 000336853 |
| Publication Details: | Published Paper ID: IJSDR2301103 Registration ID:203599 Published In: Volume 8 Issue 1, January-2023 DOI (Digital Object Identifier): Page No: 616 - 627 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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