INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
A Study of Metallo Beta Lactamases In Gram Negative Isolates In a Tertiary Care Hospital
Authors Name:
Dr. Priyanka Mategadikar
, Dr. Swati Bhise , Dr. Sunanda Shrikhande
Unique Id:
IJSDR2301095
Published In:
Volume 8 Issue 1, January-2023
Abstract:
Background- In recent years over the counter use of Antibiotics for human therapy has resulted in selection of pathogenic bacteria resistant to multiple drugs and in some cases resistant to last resort of drugs. The common form of resistance is either through lack of drug penetration or Hyper production of AmpC type β-lactamase, and Carbapenem-hydrolyzing β-lactamases. Methods- Total 2004 gram negative bacilli were tested for MBL production. Phenotypic confirmation of MBL is done by combined disk test and E strip test. Then MIC of Colistin was done by E strip test for MBL positive strains. Results- Out of 2004 samples screened 196 isolates were Imipenem resistant. Out of 196 isolates 160 were MBL producers by Combined disk test and 162 by E strip test. Out of this 162 isolates 11 isolated were Colistin resistant by E strip test. Conclusion- highest prevalence of MBL production was seen in samples from ICU. This indicated unemperical use of higher antibiotics. This suggests there is need for rational use of Antimicrobials and Culture sensitivity for every patient should be done before starting Antibiotic therapy.
Keywords:
MBL, Colistin, E strip
Cite Article:
"A Study of Metallo Beta Lactamases In Gram Negative Isolates In a Tertiary Care Hospital", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 1, page no.572 - 582, January-2023, Available :http://www.ijsdr.org/papers/IJSDR2301095.pdf
Downloads:
000337077
Publication Details:
Published Paper ID: IJSDR2301095
Registration ID:203538
Published In: Volume 8 Issue 1, January-2023
DOI (Digital Object Identifier):
Page No: 572 - 582
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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