A Study of Metallo Beta Lactamases In Gram Negative Isolates In a Tertiary Care Hospital
Dr. Priyanka Mategadikar
, Dr. Swati Bhise , Dr. Sunanda Shrikhande
Background- In recent years over the counter use of Antibiotics for human therapy has resulted in selection of pathogenic bacteria resistant to multiple drugs and in some cases resistant to last resort of drugs. The common form of resistance is either through lack of drug penetration or Hyper production of AmpC type β-lactamase, and Carbapenem-hydrolyzing β-lactamases. Methods- Total 2004 gram negative bacilli were tested for MBL production. Phenotypic confirmation of MBL is done by combined disk test and E strip test. Then MIC of Colistin was done by E strip test for MBL positive strains. Results- Out of 2004 samples screened 196 isolates were Imipenem resistant. Out of 196 isolates 160 were MBL producers by Combined disk test and 162 by E strip test. Out of this 162 isolates 11 isolated were Colistin resistant by E strip test. Conclusion- highest prevalence of MBL production was seen in samples from ICU. This indicated unemperical use of higher antibiotics. This suggests there is need for rational use of Antimicrobials and Culture sensitivity for every patient should be done before starting Antibiotic therapy.
"A Study of Metallo Beta Lactamases In Gram Negative Isolates In a Tertiary Care Hospital", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 1, page no.572 - 582, January-2023, Available :https://ijsdr.org/papers/IJSDR2301095.pdf
Volume 8
Issue 1,
January-2023
Pages : 572 - 582
Paper Reg. ID: IJSDR_203538
Published Paper Id: IJSDR2301095
Downloads: 000347195
Research Area: Medical Science
Country: Nagpur, Maharashtra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
