Case Series Of Classical Type-1 Lissencephaly

Dr.Vudatha Lakshmi meenakshi , Dr.Ayisha Sheik

Pachygyria, agyria, sub cortical band heterotopia

Abstract: Lissencephaly (LIS) is a cortical development malformation characterised by impaired neuronal migration and abnormal formation of cerebral convolutions or gyri. Agyria, pachygyria, and subcortical band heterotopia are all part of the LIS spectrum. The main difference between LIS and SBH is that LIS has an abnormally thick cortex with reduced or absent formation of cerebral convolutions, whereas SBH has abnormal bands of neurons beneath a normal cortex, though the cerebral gyri may be separated by unusually shallow sulci . A few lissencephaly patients have severe congenital microcephaly, which is known as microlissencephaly (MLIS). Miller-Dieker and Baraitser-Winter cerebrofrontofacial syndromes, as well as X-linked lissencephaly with abnormal genitalia, are examples of congenital anomaly syndromes associated with LIS. Lissencephaly is a rare genetic condition that is distinguished by a lack of cortical convolutions. It has been linked to mutations in the lissencephaly-1 (LIS1) (Reiner et al., 1993), doublecortin (DCX) (des Portes et al., 1998), and tubulin alpha 1A (TUBA1A) genes most frequently

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"Case Series Of Classical Type-1 Lissencephaly", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 1, page no.375 - 378, January-2023, Available :https://ijsdr.org/papers/IJSDR2301060.pdf

Volume 8 Issue 1, January-2023

Pages : 375 - 378

Paper Reg. ID: IJSDR_203391

Published Paper Id: IJSDR2301060

Downloads: 000347179

Research Area: Medical Science

Country: GUNTUR, ANDHRA PRADESH, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2301060

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2301060

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

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Publisher: IJSDR(IJ Publication) Janvi Wave

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