The preparation of orodispersible tablet and study effect of processing condition on Tablet

Snehal Dhewale , Bhagwan Kale , Vaishnavi Chivte , Rutuja Dhakne , Dr. Santosh Shep

CP- Co process excipient ,ssg- Sodium starch glyoclate ,ccs- Cross carmellose sodium,RT- Room temperature, IP- Indian pharmacopeia, FTIR -Fourier transform Infrared, DSC- Differential scanning calorimetry uv- Ultraviolet

In the solid dosage formulation processing condition effect on tablet in that type of tablet and different parameter main source effect on the quality for overcome this quality design product maintain all condition and term given standard result. In the research we take different batches or -dispersible tablet formulation API risperidone as super disintegrants combination sodium starch glycollate and cross carmellose sodium ratio 100 + 300 mg is showing best results .on this batch then we test effect of processing condition on tablet in tat moisture content ,humidity, temperature Moisture may have a significant impact on a wide range of chemical ,physical, and microbial properties of the finished pharmaceutical product Moisture in dosage forms comes from many sources including bulk drug, inactive excipients, manufacturing processes, and environmental conditions, and is a result of a variety of causes Water may interact in distinct ways including surface adsorption ,as a crystal hydrate, by deliquescence, and by capillary condensation .Water may have significant effects on product stability, tablet compaction ,wet granulation, powder flow properties, and microbial growth• Compliance personnel must be knowledgeable of areas with potential for moisture problems. Change control of these areas is especially important to maintain compliant manufacturing. Be prepared for potential problems. The effects of moisture should be considered in trouble shooting investigations and root cause analyses we take batches F1 to F 9 different humidity and temperature appropriate result shown by F5 batch then again we test compressibility for all physical properties and nature ingredients and API , elasticity and plasticity effect on compressibility of tablet then different compressibility test fromC1 to C5 best result shown by C3 .

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"The preparation of orodispersible tablet and study effect of processing condition on Tablet", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 1, page no.115 - 132, January-2023, Available :https://ijsdr.org/papers/IJSDR2301021.pdf

Volume 8 Issue 1, January-2023

Pages : 115 - 132

Paper Reg. ID: IJSDR_203376

Published Paper Id: IJSDR2301021

Downloads: 000347216

Research Area: Pharmacy

Country: KHAMGAON, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2301021

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2301021

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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