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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | The preparation of orodispersible tablet and study effect of processing condition on Tablet |
| Authors Name: | Snehal Dhewale , Bhagwan Kale , Vaishnavi Chivte , Rutuja Dhakne , Dr. Santosh Shep |
| Unique Id: | IJSDR2301021 |
| Published In: | Volume 8 Issue 1, January-2023 |
| Abstract: | In the solid dosage formulation processing condition effect on tablet in that type of tablet and different parameter main source effect on the quality for overcome this quality design product maintain all condition and term given standard result. In the research we take different batches or -dispersible tablet formulation API risperidone as super disintegrants combination sodium starch glycollate and cross carmellose sodium ratio 100 + 300 mg is showing best results .on this batch then we test effect of processing condition on tablet in tat moisture content ,humidity, temperature Moisture may have a significant impact on a wide range of chemical ,physical, and microbial properties of the finished pharmaceutical product Moisture in dosage forms comes from many sources including bulk drug, inactive excipients, manufacturing processes, and environmental conditions, and is a result of a variety of causes Water may interact in distinct ways including surface adsorption ,as a crystal hydrate, by deliquescence, and by capillary condensation .Water may have significant effects on product stability, tablet compaction ,wet granulation, powder flow properties, and microbial growth• Compliance personnel must be knowledgeable of areas with potential for moisture problems. Change control of these areas is especially important to maintain compliant manufacturing. Be prepared for potential problems. The effects of moisture should be considered in trouble shooting investigations and root cause analyses we take batches F1 to F 9 different humidity and temperature appropriate result shown by F5 batch then again we test compressibility for all physical properties and nature ingredients and API , elasticity and plasticity effect on compressibility of tablet then different compressibility test fromC1 to C5 best result shown by C3 . |
| Keywords: | CP- Co process excipient ,ssg- Sodium starch glyoclate ,ccs- Cross carmellose sodium,RT- Room temperature, IP- Indian pharmacopeia, FTIR -Fourier transform Infrared, DSC- Differential scanning calorimetry uv- Ultraviolet |
| Cite Article: | "The preparation of orodispersible tablet and study effect of processing condition on Tablet", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 1, page no.115 - 132, January-2023, Available :http://www.ijsdr.org/papers/IJSDR2301021.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2301021 Registration ID:203376 Published In: Volume 8 Issue 1, January-2023 DOI (Digital Object Identifier): Page No: 115 - 132 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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