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Paper Title: Facile Synthesis and Studies of 1,5-Benzothiazepine-2-carboxylic Acids
Authors Name: Seema Pant , Pushpa Godwal , Radheshyam Kasana , Gajendra Singh Shekhawat , Chandra Bhushan Jain
Unique Id: IJSDR2212196
Published In: Volume 7 Issue 12, December-2022
Abstract: A series of 8-substituted-2,3-dihydro-1,5-benzothiazepine-2-carboxylic acids were synthesized by one-pot reactions of six 5-substituted-2-amino benzenethiols, the substitutes being fluoro, chloro, bromo, methyl, methoxy and ethoxy; and substituted β -benzoyl acrylic acid in ethanol utilizing glacial acetic acid as catalyst in 59-85% yields. The structures of compounds were characterized by FT-IR, NMR, and elemental analysis. Antimicrobial activities of these compounds were determined by using paper disc method against the gram-positive and gram-negative bacteria, Staphylococcus aureus and Escherichia coli respectively; and against the fungus, Candida albicans.
Keywords: β-benzoyl acrylic acid, 1,5-benzothiazepine-2-carboxylic acids, Staphylococcus aureus, Escherichia coli, Candida albicans
Cite Article: "Facile Synthesis and Studies of 1,5-Benzothiazepine-2-carboxylic Acids", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 12, page no.1206 - 1209, December-2022, Available :http://www.ijsdr.org/papers/IJSDR2212196.pdf
Downloads: 000201547
Publication Details: Published Paper ID: IJSDR2212196
Registration ID:203316
Published In: Volume 7 Issue 12, December-2022
DOI (Digital Object Identifier):
Page No: 1206 - 1209
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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