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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Facile Synthesis and Studies of 1,5-Benzothiazepine-2-carboxylic Acids |
| Authors Name: | Seema Pant , Pushpa Godwal , Radheshyam Kasana , Gajendra Singh Shekhawat , Chandra Bhushan Jain |
| Unique Id: | IJSDR2212196 |
| Published In: | Volume 7 Issue 12, December-2022 |
| Abstract: | A series of 8-substituted-2,3-dihydro-1,5-benzothiazepine-2-carboxylic acids were synthesized by one-pot reactions of six 5-substituted-2-amino benzenethiols, the substitutes being fluoro, chloro, bromo, methyl, methoxy and ethoxy; and substituted β -benzoyl acrylic acid in ethanol utilizing glacial acetic acid as catalyst in 59-85% yields. The structures of compounds were characterized by FT-IR, NMR, and elemental analysis. Antimicrobial activities of these compounds were determined by using paper disc method against the gram-positive and gram-negative bacteria, Staphylococcus aureus and Escherichia coli respectively; and against the fungus, Candida albicans. |
| Keywords: | β-benzoyl acrylic acid, 1,5-benzothiazepine-2-carboxylic acids, Staphylococcus aureus, Escherichia coli, Candida albicans |
| Cite Article: | "Facile Synthesis and Studies of 1,5-Benzothiazepine-2-carboxylic Acids", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 12, page no.1206 - 1209, December-2022, Available :http://www.ijsdr.org/papers/IJSDR2212196.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2212196 Registration ID:203316 Published In: Volume 7 Issue 12, December-2022 DOI (Digital Object Identifier): Page No: 1206 - 1209 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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