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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Comprehensive Witting approach toward advancements in synthetic strategies and the pharmacological evaluation of isoxazole analogues through the angle of medicinal chemistry |
| Authors Name: | Hritik Verma , Varsha Snehi , Devender Pathak , Sunam Saha , Shivendra Kumar |
| Unique Id: | IJSDR2212195 |
| Published In: | Volume 7 Issue 12, December-2022 |
| Abstract: | Isoxazole is a group of molecules required for physiological activity. The isoxazole moiety is the most prevalent moiety identified in commercially available pharmaceuticals, indicating a strong interest in the formation of functional 1,2-oxazole. Several techniques for synthesis of functional 1,2-oxazoles are discussed in this article. Integrating the isoxazole ring may result in enhanced physical and chemical characteristics. Isoxazole rings have been a popular moiety for compound creation because to their distinct profile. Disubstituted and trisubstituted isoxazoles appear to exhibit a variety of biological functions as well. Pain - relieving and typical anti-inflammatory abilities, as well as antioxidant and anticancer effect, CNS (central nervous system) action, and anti - tuberculosis activity. They also have GABA antagonistic and inhibitory properties, as well as antihypertensive and glutamate transporter activities. The major focus of this systematic review has been on how the isoxazole moiety may be utilized to heal a range of illnesses such as Alzheimer's, TB, pain, and inflammation, as well as how to synthesize novel molecules. There has been a considerable discussion on what the future holds and the patterns for utilizing it. This study intends to highlight advances in the chemical behaviour and bioactivities of isoxazole analogues that may provide medicinal researchers with a low-height flying bird's eye perspective on isoxazole derivatives for the development of clinically viable drugs utilizing this knowledge. |
| Keywords: | Isoxazole, Synthetic methods, Anti-Alzheimer, Analgesic, Anti-inflammatory. |
| Cite Article: | "Comprehensive Witting approach toward advancements in synthetic strategies and the pharmacological evaluation of isoxazole analogues through the angle of medicinal chemistry", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 12, page no.1191 - 1205, December-2022, Available :http://www.ijsdr.org/papers/IJSDR2212195.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2212195 Registration ID:203289 Published In: Volume 7 Issue 12, December-2022 DOI (Digital Object Identifier): Page No: 1191 - 1205 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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