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| Paper Title: | Formulation and evaluation of pulsatile drug delivery system of atorvastatin using press coating technique |
| Authors Name: | Manjula R. , Keerthi H. S. , Shivanand K. Mutta , Sowmya T. P. , Pradeep Kumar Patel |
| Unique Id: | IJSDR2212166 |
| Published In: | Volume 7 Issue 12, December-2022 |
| Abstract: | The objective of present investigation is to formulate and evaluate press coated tablet for pulsatile drug delivery system of Atorvastatin, which can be taken at bed time (10pm) and capable of releasing the drug between night and early morning hours after predetermined time delay (4 hr), when free cholesterol levels are more prevalent, can prevent various heart diseases like atherosclerosis, stroke, angina and myocardial infarction. The rationale of this study is to achieve sequential release of Atorvastatin that suits the biological requirement (circadian rhythm) of hypercholesterolemia. The press coated tablets containing Atorvastatin have been made by incorporating crosspovidone by direct compression method with an outer coating of different ratios of Xanthun gum and guar gum. The disintegration time and percentage drug release was analysed for all prepared tablets from each formulation. Drug excipients compatibility has been studied by FT-IR spectroscopic studies. The formulated tablets were evaluated by stability, friability, drug content uniformity tests. Result of in-vitro dissolution study of the formulated tablet was suggested that, the release of drug from pulsatile unit match with the chronobiological requirement of disease. |
| Keywords: | Pulsatile drug delivery system, hypercholesterolemia, circadian rhythm, Atorvastatin. |
| Cite Article: | "Formulation and evaluation of pulsatile drug delivery system of atorvastatin using press coating technique ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 12, page no.1048 - 1051, December-2022, Available :http://www.ijsdr.org/papers/IJSDR2212166.pdf |
| Downloads: | 000201539 |
| Publication Details: | Published Paper ID: IJSDR2212166 Registration ID:203209 Published In: Volume 7 Issue 12, December-2022 DOI (Digital Object Identifier): Page No: 1048 - 1051 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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