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Paper Title: Green Synthesis and Docking Studies of Novel Coupled chromonyl thiadiazolyl Derivatives by Kabachnik - Fields reaction
Unique Id: IJSDR2212143
Published In: Volume 7 Issue 12, December-2022
Abstract: The work reports facile synthesis of novel ten α-aminophosphonate derivatives coupled with 3-formyl chromone moiety, namely diethyl ((4-oxo-4H-chromen-3-yl)((5-sustituted phenyl-1,3,4-thiadiazol-2-yl)amino)methyl)phosphonate 6(a-j). The derivatives 6(a-j) were synthesized through one-pot three component Kabachnik-Fields reaction, by using ultrasound in presence of zirconium oxychloride (ZrOCl2) as a catalyst, to give the final compounds in better yields and in shorter reaction time. Thiadiazole and its derivatives possess a broad range of biological and pharmacological properties. 5-substituted phenyl-1,3,4-thiadiazol-2-amine is widely used as starting material for the synthesis of a broad range of heterocyclic compounds and as substrates for drug synthesis. Several 3-formylchromone derivatives possess a broad range of biological and pharmacological properties. The α-amino phosphonate derivatives constitute an important class of organophosphorus compounds on account of their versatile biological activity. Considering the importance of the three pharmacophores, promoted us to club all pharmacophores in a single molecule using green protocol. The Principles of Green chemistry are followed while performing the synthesis.
Keywords: Kabachnik-Fields reaction; Ultrasound, thiadiazol; 3-formyl chromone; α-amino phosphonate; zirchonium oxychloride
Cite Article: "Green Synthesis and Docking Studies of Novel Coupled chromonyl thiadiazolyl Derivatives by Kabachnik - Fields reaction", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 12, page no.915 - 929, December-2022, Available :http://www.ijsdr.org/papers/IJSDR2212143.pdf
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Publication Details: Published Paper ID: IJSDR2212143
Registration ID:203215
Published In: Volume 7 Issue 12, December-2022
DOI (Digital Object Identifier):
Page No: 915 - 929
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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