Formulation and Evaluation of floating matrix tablet captopril
Mr.Sagar R.Koli
, Mr.Chandranil D.Ishi , Mr.Mahesh P. Pawar
Floating matrix tablet, Captopril, In-vitrorelease.
The present study involves preparation and evaluation of floating matrix tablet of Captopril as model drug for prolongation of gastric residence time. The tablets were prepared by Direct compression method using polymers HPMC (K4M), HPMC (K4M), Xantham gum and Guar gum. The tablet were evaluated for angle of repose, bulk density, tapped density, carr’s index, hausner’s ratio. The prepared tablets were characterized by hardness, thickness, friability, weight variation and drug content respectively. In-vitro drug release studies were performed by using an USP dissolution test apparatus (Basket type II) at 37±0.5ºC and 50 rpm speed. To study the release behavior, kinetic analyses were performed on the optimized formulation. The dissolution data were fitted to zero order, first order, matrix, Hixson-Crowell, Peppas model. The prepared tablet exhibited prolonged drug release (~ 12 h) and remained buoyant for > 12 h. The optimized formulations F13 were kept for short term stability study. The conditions for stability study were 40ºC and relative humidity of 75% from the study; it was observed that there is no significant change in stability and drug release rate.
"Formulation and Evaluation of floating matrix tablet captopril", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 11, page no.1126 - 1154, November-2022, Available :https://ijsdr.org/papers/IJSDR2211169.pdf
Volume 7
Issue 11,
November-2022
Pages : 1126 - 1154
Paper Reg. ID: IJSDR_202780
Published Paper Id: IJSDR2211169
Downloads: 000347263
Research Area: Pharmacy
Country: Dhule, Maharashta, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
