INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Mechanistic and kinetic study of oxidation of topiramate anti-epileptic drug by permanganate in aqueous alkaline medium.
Authors Name:
S.yamuna princy
, Dr. Nalini
Unique Id:
IJSDR2211154
Published In:
Volume 7 Issue 11, November-2022
Abstract:
Abstract: The kinetics and mechanism of oxidation of antiepileptic drug Topiramate [TPM] was investigated in aqueous alkaline medium under pseudo first order condition. The experimental results indicated that the reaction exhibits fractional order concerning Topiramate and first order concerning potassium permanganate [KmnO4]. The reaction stoichiometry shows one mole of amlodipine besylate consumes one mole of potassium permanganate. The effect of temperature on the reaction rate is studied and the activation parameters are calculated and tabulated. A scheme is proposed based on which a reaction mechanism is proposed. LC-MS Technique was used to identify the oxidation product of topiramate. Based on the experimental results, a mechanism is proposed and constant K1, K2 and k3 involved in the mechanism were evaluated. The observed rate constant values and the values calculated by substituting the value K2 = 531.3 k = 0.027 and K1 5.42 x 10-3 are found to be in good accordance with KCal values.
Keywords:
KINETICS, MECHANISM, TOPIRAMATEand OXIDATION.
Cite Article:
"Mechanistic and kinetic study of oxidation of topiramate anti-epileptic drug by permanganate in aqueous alkaline medium.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 11, page no.1045 - 1050, November-2022, Available :http://www.ijsdr.org/papers/IJSDR2211154.pdf
Downloads:
000337071
Publication Details:
Published Paper ID: IJSDR2211154
Registration ID:202683
Published In: Volume 7 Issue 11, November-2022
DOI (Digital Object Identifier):
Page No: 1045 - 1050
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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