Mechanistic and kinetic study of oxidation of topiramate anti-epileptic drug by permanganate in aqueous alkaline medium.
S.yamuna princy
, Dr. Nalini
KINETICS, MECHANISM, TOPIRAMATEand OXIDATION.
Abstract: The kinetics and mechanism of oxidation of antiepileptic drug Topiramate [TPM] was investigated in aqueous alkaline medium under pseudo first order condition. The experimental results indicated that the reaction exhibits fractional order concerning Topiramate and first order concerning potassium permanganate [KmnO4]. The reaction stoichiometry shows one mole of amlodipine besylate consumes one mole of potassium permanganate. The effect of temperature on the reaction rate is studied and the activation parameters are calculated and tabulated. A scheme is proposed based on which a reaction mechanism is proposed. LC-MS Technique was used to identify the oxidation product of topiramate. Based on the experimental results, a mechanism is proposed and constant K1, K2 and k3 involved in the mechanism were evaluated. The observed rate constant values and the values calculated by substituting the value K2 = 531.3 k = 0.027 and K1 5.42 x 10-3 are found to be in good accordance with KCal values.
"Mechanistic and kinetic study of oxidation of topiramate anti-epileptic drug by permanganate in aqueous alkaline medium.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 11, page no.1045 - 1050, November-2022, Available :https://ijsdr.org/papers/IJSDR2211154.pdf
Volume 7
Issue 11,
November-2022
Pages : 1045 - 1050
Paper Reg. ID: IJSDR_202683
Published Paper Id: IJSDR2211154
Downloads: 000347188
Research Area: Chemistry
Country: Bangalore, Karnataka, india
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
