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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Isolation, Speciation and Antifungal drug Susceptibility of Candida species isolated from various clinical specimens in a tertiary care hospital |
| Authors Name: | Dr. Divya Patil , Dr. Ashwini Patil , Dr S.S. Zodpey (Shrikhande) |
| Unique Id: | IJSDR2211134 |
| Published In: | Volume 7 Issue 11, November-2022 |
| Abstract: | Background- Over the last 20 years, the rates of fungal infection have increased and Candida has emerged as a major cause of human disease. Candida species cause various clinical infections ranging from mucocutaneous infections to life threatening blood stream infections. Emergence of Candida species resistance is on the rise especially to triazoles and amphotericin B has led to use echinocandins, mostly caspofungin in the management of invasive candidiasis. The aim of the study was to identify the spectrum of Candida species and to determine the susceptibility pattern to antifungal agents. Methods- A total of 150 Candida isolates were isolated over a period of 2 years. Growth of each isolate was evaluated for colony appearance, Gram stain, Germ tube test, morphological appearance by Dalmau technique using cornmeal agar, sugar utilization test, Culture on CHROMagar for species identification was done for species identification. Antifungal susceptibility was performed as recommended by Clinical and Laboratory Standards Institute (CLSI) M44-A2 document. Results- Out of 150 Candida isolates, C.albicans was the most common species. 40% isolates obtained were from age group >60 years. Majority of Candida isolates, 52(34.67%) were from patients who had immunosuppression & chronic drug therapy as predisposing factor. Among the non- albicans Candida species C. tropicalis (27.33%) was predominant isolate followed by C. glabrata (16%). Regarding antifungal susceptibility pattern, Candida species were more resistant to fluconazole (20.67%) followed by ketoconazole (8.66%) and voriconazole (6.67%). Conclusion- Due to the variable clinical presentations of Candida infections, it becomes very important to identify these pathogens from all the routine culture specimens received irrespective of clinical diagnosis. Candida spp. differ in their antifungal susceptibility and virulence factors. Thus, routine identification of Candida up to species level along with antifungal susceptibility becomes very essential in diagnostic microbiology laboratory. |
| Keywords: | Antifungal susceptibility testing, Susceptible Dose Dependent, Candida |
| Cite Article: | "Isolation, Speciation and Antifungal drug Susceptibility of Candida species isolated from various clinical specimens in a tertiary care hospital", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 11, page no.931 - 936, November-2022, Available :http://www.ijsdr.org/papers/IJSDR2211134.pdf |
| Downloads: | 000337067 |
| Publication Details: | Published Paper ID: IJSDR2211134 Registration ID:202623 Published In: Volume 7 Issue 11, November-2022 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.32878 Page No: 931 - 936 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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