Welcome to IJSDR UGC CARE norms ugc approved journal norms IJRTI Research Journal | ISSN : 2455-2631
IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.15 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)

Issue: November 2022

Volume 7 | Issue 11

Impact factor: 8.15

Click Here For more Info

Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter

Copyright Infringement Claims
Indexing Partner
Published Paper Details
Paper Title: Isolation, Speciation and Antifungal drug Susceptibility of Candida species isolated from various clinical specimens in a tertiary care hospital
Authors Name: Dr. Divya Patil , Dr. Ashwini Patil , Dr S.S. Zodpey (Shrikhande)
Unique Id: IJSDR2211134
Published In: Volume 7 Issue 11, November-2022
Abstract: Background- Over the last 20 years, the rates of fungal infection have increased and Candida has emerged as a major cause of human disease. Candida species cause various clinical infections ranging from mucocutaneous infections to life threatening blood stream infections. Emergence of Candida species resistance is on the rise especially to triazoles and amphotericin B has led to use echinocandins, mostly caspofungin in the management of invasive candidiasis. The aim of the study was to identify the spectrum of Candida species and to determine the susceptibility pattern to antifungal agents. Methods- A total of 150 Candida isolates were isolated over a period of 2 years. Growth of each isolate was evaluated for colony appearance, Gram stain, Germ tube test, morphological appearance by Dalmau technique using cornmeal agar, sugar utilization test, Culture on CHROMagar for species identification was done for species identification. Antifungal susceptibility was performed as recommended by Clinical and Laboratory Standards Institute (CLSI) M44-A2 document. Results- Out of 150 Candida isolates, C.albicans was the most common species. 40% isolates obtained were from age group >60 years. Majority of Candida isolates, 52(34.67%) were from patients who had immunosuppression & chronic drug therapy as predisposing factor. Among the non- albicans Candida species C. tropicalis (27.33%) was predominant isolate followed by C. glabrata (16%). Regarding antifungal susceptibility pattern, Candida species were more resistant to fluconazole (20.67%) followed by ketoconazole (8.66%) and voriconazole (6.67%). Conclusion- Due to the variable clinical presentations of Candida infections, it becomes very important to identify these pathogens from all the routine culture specimens received irrespective of clinical diagnosis. Candida spp. differ in their antifungal susceptibility and virulence factors. Thus, routine identification of Candida up to species level along with antifungal susceptibility becomes very essential in diagnostic microbiology laboratory.
Keywords: Antifungal susceptibility testing, Susceptible Dose Dependent, Candida
Cite Article: "Isolation, Speciation and Antifungal drug Susceptibility of Candida species isolated from various clinical specimens in a tertiary care hospital", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 11, page no.931 - 936, November-2022, Available :http://www.ijsdr.org/papers/IJSDR2211134.pdf
Downloads: 000150694
Publication Details: Published Paper ID: IJSDR2211134
Registration ID:202623
Published In: Volume 7 Issue 11, November-2022
DOI (Digital Object Identifier):
Page No: 931 - 936
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

Click Here to Download This Article

Article Preview

Click here for Article Preview







Major Indexing from www.ijsdr.org
Google Scholar ResearcherID Thomson Reuters Mendeley : reference manager Academia.edu
arXiv.org : cornell university library Research Gate CiteSeerX DOAJ : Directory of Open Access Journals
DRJI Index Copernicus International Scribd DocStoc

Track Paper
Important Links
Conference Proposal
ISSN
DOI (A digital object identifier)


Providing A digital object identifier by DOI
How to GET DOI and Hard Copy Related
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Creative Commons License
This material is Open Knowledge
This material is Open Data
This material is Open Content
Social Media
IJSDR

Indexing Partner