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Issue: November 2022

Volume 7 | Issue 11

Impact factor: 8.15

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Paper Title: Formulation of Gastroretentive Floating Tablet Using Cross-linked Sterculia foetida gum
Authors Name: Lokesh P. Kothari , Dr. Atish S. Mundada
Unique Id: IJSDR2211110
Published In: Volume 7 Issue 11, November-2022
Abstract: Semi synthetic or Natural materials have been gaining lot of interest in the field of drug delivery as they are readily available, cost effective, eco-friendly and compatible due to their natural origin. The purpose of the present research was to develop gastroretentive floating tablets of Diltiazem hydrochloride using modified Sterculia foetida gum. Physicochemical characterization like Viscosity, pH, X-ray diffraction of modified SFG was done. A 32 full factorial design (nine runs) was utilized to optimize the formulation wherein the concentration of modified SFG (X1) and concentration of effervescent agent(X2) were taken as independent variables and Cumulative % drug release upto 12hr (Y1) and buoyancy lag time (BLT) (Y2) were taken as dependant variables. The quantitative, as well as qualitative influence of factor on the response, was thoroughly investigated using Design Expert® software (version 13; Stat-Ease, Inc., Minneapolis, MN, USA).. Software generated polynomial equations were utilized to understand the significant interaction among the factors and responses. The Optimized formulations of the tablets were compared with the tablets prepared with natural SFG. The results revealed that, the modified SFG gum has higher drug release retarding capacity than that of natural SFG. The FTIR results indicated that there were no interactions of modified SFG with Diltiazem hydrochloride. It can be concluded from the outcome of the present investigation that modified SFG has good potentials for formulating gastroretentive floating drug delivery system.
Keywords: Sterculia foetida gum (SFG), floating drug delivery system (FDDS), Diltiazem hydrochloride (DH), Buoyancy lag time (BLT), full factorial design etc.
Cite Article: "Formulation of Gastroretentive Floating Tablet Using Cross-linked Sterculia foetida gum", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 11, page no.790 - 801, November-2022, Available :http://www.ijsdr.org/papers/IJSDR2211110.pdf
Downloads: 000150694
Publication Details: Published Paper ID: IJSDR2211110
Registration ID:202682
Published In: Volume 7 Issue 11, November-2022
DOI (Digital Object Identifier):
Page No: 790 - 801
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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