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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Head and Neck Lymphatic Obstruction and Dysphagia Following Chemo-radiotherapy for Head and Neck Cancer A Retrospective, Linear, and Experimental Research |
| Authors Name: | Dr. Tshetiz Dahal , Anusiyan Alagan , Subarna Rizal , Manoj Kharka |
| Unique Id: | IJSDR2211037 |
| Published In: | Volume 7 Issue 11, November-2022 |
| Abstract: | The study's objectives were to investigate (a) the development of external and internal head and neck lymphoedema (HNL) in head and neck cancer (HNC) patients up to 12 months after chemo-radiotherapy (CRT), and (b) the association between HNL and swallowing performance. External/internal HNL and swallowing were assessed in 33 patients using a prospective longitudinal cohort study at 3, 6, and 12 months after CRT. Using the MD Anderson Cancer Center Lymphoedema Rating Scale and the Assessment of Lymphoedema of the Head and Neck, external HNL was evaluated. Using Patterson's Radiotherapy Oedema Rating Scale, internal HNL was evaluated. Clinical, instrumental, and patient-reported assessments were used to evaluate swallowing. Multi-variable regression models were used to evaluate the relationships between HNL and swallowing. External HNL was prevalent at 3 months (71%), improved by 6 months (58%) and largely resolved by 12 months (10%). In contrast, moderate/severe internal HNL was prevalent at 3 months (96%), 6 months (84%) and at 12 months (65%). More severe penetration/aspiration and increased diet modification were associated with higher severities of external HNL (p=0.006 and p=0.031, respectively) and internal HNL (p<0.001 and p=0.007, respectively), and more diffuse internal HNL (p=0.043 and p=0.001, respectively). Worse patient-reported swallowing outcomes were associated with a higher severity of external HNL (p=0.001) and more diffuse internal HNL (p=0.002). External HNL largely resolves by 12 months post CRT, but internal HNL persists. Patients with a higher severity of external and/or internal HNL and those with more diffuse internal HNL can be expected to have more severe dysphagia. |
| Keywords: | Head and Neck Cancer, Radiotherapy, Lymphoedema, Dysphagia, Deglutition, Deglutition disorders, Swallowing, Chemotherapy, Radiotherapy, Speech pathology, Lymphatic obstruction |
| Cite Article: | "Head and Neck Lymphatic Obstruction and Dysphagia Following Chemo-radiotherapy for Head and Neck Cancer A Retrospective, Linear, and Experimental Research", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 11, page no.224 - 235, November-2022, Available :http://www.ijsdr.org/papers/IJSDR2211037.pdf |
| Downloads: | 000337074 |
| Publication Details: | Published Paper ID: IJSDR2211037 Registration ID:202492 Published In: Volume 7 Issue 11, November-2022 DOI (Digital Object Identifier): Page No: 224 - 235 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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