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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Fluoride toxicity on detoxification mechanism mitigated by Vit-C in the selected tissues of Albino rat |
| Authors Name: | P.Jacob Doss , G. Meena Kumari , T. Yamini , K. Vimala , S.V. Ravikanth |
| Unique Id: | IJSDR2210198 |
| Published In: | Volume 7 Issue 10, October-2022 |
| Abstract: | The metabolites and antioxidant enzymes involving in detoxification metabolism are severely prone to NaF stress, In India contaminated ground water has a fluoride level up to 25mg/l and continuous ingestion of fluoride contaminated water results in fluoride poisoning. The results of the present study clearly indicate that administration of fluoride causes significant alterations in the antioxidant enzymes in all the tissues of Albino rats. . The animals were orally administered 4.4mg/kg body weight (i.e. 1/10th of LD50 ) of NaF for 28 days with an interval of 24h to induce the toxic effects of fluoride in Albino rats. 200mg/kg/day of vitamin C was given orally.. We observed significant alterations in antioxidant enzymes when compared between NaF exposed rats and NaF + Vitamin C treated rats. Four groups of animals were taken, first group is control, II group was exposed to vit-C for 28 days, III group exposed to NaF for 28 days and IV group exposed to NaF+Vit-C for 28 days. The dosing schedule ranging from 1 to 28 days with an interval of 24 h. was observed. The animals were sacrificed on 29th day by cervical dislocation and the tissues were isolated. and processed immediately for histopathological evaluation and the remaining tissue is stored at -80oC for further biochemical analysis. The results of the present study clearly indicate that exposure to fluoride levels caused a significant elevation in the LPO and XOD levels. On the other hand SOD, CAT, GPx and GR showed a sharp decline in all the tissues of fluoride intoxicated rats. The alterations in the antioxidant cascade in the fluoride exposed rats clearly indicate the onset of oxidative stress resulting in peroxidation of unsaturated membrane lipids. When a combination of NaF and Vitamin C was used a significant recovery in the antioxidant enzymes. vitamin C can scavenge free radicals directly and can also have positive effects by renewing the antioxidant enzymes which are observed in all the tissues. The results of the present investigation suggest that Vitamin C treatment can ameliorate the toxic effects of NaF related to antioxidant enzymes. |
| Keywords: | Sodium Fluoride, Vitamin C, Albino Rats , Detoxification Enzymes. |
| Cite Article: | "Fluoride toxicity on detoxification mechanism mitigated by Vit-C in the selected tissues of Albino rat", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 10, page no.1159 - 1162, October-2022, Available :http://www.ijsdr.org/papers/IJSDR2210198.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2210198 Registration ID:202397 Published In: Volume 7 Issue 10, October-2022 DOI (Digital Object Identifier): Page No: 1159 - 1162 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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