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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A Review of Management of Hepatocellular Carcinoma. |
| Authors Name: | Aamir Majeed Shah , Manzoor Hussain , Tahir Khan , Irfan Robbani , Feroz Shaheen |
| Unique Id: | IJSDR2210187 |
| Published In: | Volume 7 Issue 10, October-2022 |
| Abstract: | Hepatocellular carcinoma represents about 90% of primary liver cancers and constitutes a major global health problem. HCC can be cured with surgical removal of the tumor, especially when the tumour is small and liver function is preserved. A liver tumour is usually treated by removing the area of the organ in which it is found. However, partial hepatectomy raises the risk of another HCC developing in the residual liver, which occurs in around half of the cases. Liver transplantation is often the most effective treatment for HCC when resection is unlikely to be successful due to the risk of liver failure or cancer recurrence. The requirement to protect native liver function during surgery is avoided with a liver transplant, which dramatically reduces the risk of cancer recurrence. The recurrence rate for HCC following transplantation is 10–20%, which is significantly lower than the resection rate. Other therapeutic approaches, such as percutaneous ablation, transarterial chemoembolization (TACE), radioembolization, external radiation, systemic molecular targeted therapy, or immunotherapy, may be appropriate for a select group of patients with small, favourably located tumors. In patients with more advanced HCC, effective treatment is also available. TACE, in which a chemotherapeutic cocktail is injected directly into the tumour and its blood supply is cut off, causes tumour death and is effective at controlling even larger tumors. TACE can also be used to keep tumours from growing while patients with smaller tumours are on the liver transplant waiting list. Radioembolization is a treatment that involves injecting radiation-emitting beads into the tumour as an alternative to TACE. Microspheres are injected into the portal vein to block off blood flow to the tumour during portal vein embolization. Without a doubt, systemic HCC therapies have reached their prime. Angiogenesis and immune evasion are two common features of cancers. The atezolizumab + bevacizumab regimen is a pioneer in the era of immunological combination therapy and the first to be shown to be more efficient than sorafenib in the first-line treatment of advanced HCC, which is regarded as a milestone and an encouraging breakthrough in the treatment of advanced HCC. Despite the fact that HCC is a fatal condition, early screening and diagnosis offer the best opportunity for a long life. Due to the intricacy of the condition, patients are frequently best treated in facilities with experience in managing HCC, where a multidisciplinary approach can be applied. A condition that was once believed to be fatal only a few decades ago has improved in terms of survival and prognosis thanks to improvements in HCC prevention, early recognition, and therapy. |
| Keywords: | HCC Management, BCLC, Intervention Radiology |
| Cite Article: | " A Review of Management of Hepatocellular Carcinoma.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 10, page no.1097 - 1107, October-2022, Available :http://www.ijsdr.org/papers/IJSDR2210187.pdf |
| Downloads: | 000337068 |
| Publication Details: | Published Paper ID: IJSDR2210187 Registration ID:202359 Published In: Volume 7 Issue 10, October-2022 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.32265 Page No: 1097 - 1107 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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