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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Paper Title: Assessment of dose to Lacrimal Glands in Carcinoma Nasopharynx, Nasal Cavity and Paranasal Sinuses and its clinical importance
Authors Name: S.K.Azharuddin , Piyush Kumar
Unique Id: IJSDR2210133
Published In: Volume 7 Issue 10, October-2022
Abstract: Abstract Introduction Head and Neck cancers comprises of heterogeneous group of tumors with significant mortality and morbidity causing all around the world. Carcinoma Nasopharynx, Nasal cavity and Para-nasal sinuses tumors are a distinct group of tumors within head and neck cancers with slight variation in treatment approach. Recent trends in conformal techniques of radiotherapy led to exploration of long-term toxicities caused by the various Organs at risk (OAR’s). Lacrimal glands as an Organ at risk (OAR) is being evaluated recently due its ocular toxicities. Lacrimal gland produces the majority of tear fluid. Dry eye syndrome and Kerato-conjunctivitis is a complication of radiotherapy to the periorbital region. Studies have shown that the tolerance of lacrimal gland is V30 less than 50% and Dose maximum (Dmax) less than 40Gy. Material and Methods Twenty-three patients of Carcinoma NPX, NC and PNS already treated with IMRT/3DCRT in our Institute from 2017 to 2021 were included. Contouring and planning done on Eclipse Treatment Planning system version 13.6 according to RTOG guidelines. Dose to PTV was 60-70Gy with/without concurrent chemotherapy. Retrospectively, Right and left lacrimal gland was contoured according to the guidelines by Freedman et al and the dosimetric parameters of Dmin, Dmax and Dmean along with V10,V20,V30 to the lacrimal glands were evaluated. Patient’s were evaluated for any ocular signs and symptoms and ophthalmological examination done with Schirmers tests, Tear Break Up Time (TBUT) and visual acuity tests and all these parameters are statistically correlated with Pearson correlation coefficient. Results The mean, max and min doses to left lacrimal gland are 9.46Gy, 15.2Gy, 5.65Gy respectively, where as for right lacrimal gland they were 11.58Gy, 18.57Gy, 6.9Gy respectively. The volumetric doses of V10, V20 and V30 for left side are 29.7%, 8.9%, 4.75% and 81.4%, 12.8% and 4.4% for right side. There is a positive correlation although with weak relationship between the visual problems and dosimetric parameters of mean, max and V10 and V20 with no correlation for V30. Conclusion This study demonstrates that the dose received by lacrimal glands may have resulted in visual difficulties however further large scale studies with long term follow up may help in further concluding the relationship between dose and clinical outcomes.
Keywords: Lacrimal glands, ocular toxicities, dry eyes, nasopharynx, nasal cavity, paranasal sinuses, IMRT, 3DCRT, head and neck cancers
Cite Article: "Assessment of dose to Lacrimal Glands in Carcinoma Nasopharynx, Nasal Cavity and Paranasal Sinuses and its clinical importance", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 10, page no.778 - 781, October-2022, Available :http://www.ijsdr.org/papers/IJSDR2210133.pdf
Downloads: 000336257
Publication Details: Published Paper ID: IJSDR2210133
Registration ID:202357
Published In: Volume 7 Issue 10, October-2022
DOI (Digital Object Identifier):
Page No: 778 - 781
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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