INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Syntheses, Structural Evaluation and Antimicrobial Studies of Substituted -1,5-benzothiazepines
Authors Name:
Dr. Seema Pant
, Dr. Chandra Bhushan Jain
Unique Id:
IJSDR2210046
Published In:
Volume 7 Issue 10, October-2022
Abstract:
The enolizable ketone, 1-(4-nitrophenyl)-3-(4-chlorophenyl)-1-prop-2-enone was reacted with six 5-substituted-2-aminobenzenethiols in dry ethanol containing dry hydrogen chloride, to obtain the series of 8-substituted-2,5-dihydro-4-(4-chlorophenyl)-2-(4-nitrophenyl)-1,5-benzothiazepines in yields ranging from 40-49%. The structure of the final products has been elucidated by micro estimation for C, H and N; and IR, 1H NMR, and mass spectroscopies. The low yield of the products may be due to the presence of deactivating nitro group. The compounds have the potential of showing some useful bioactivities so the synthesized compounds were studied for their relative antimicrobial activity by selecting gram-positive bacteria Staphylococcus aureus and gram-negative bacteria Pseudomonas aeruginosa against the reference compound Vancomycin and Amikacin respectively. The activity of these compounds against the fungi, Candida albicans and Aspergillus niger was also studied. A few compounds showed very good antifungal activity with respect to the reference standards, against Candida albicans and Aspergillus niger.
"Syntheses, Structural Evaluation and Antimicrobial Studies of Substituted -1,5-benzothiazepines", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 10, page no.270 - 274, October-2022, Available :http://www.ijsdr.org/papers/IJSDR2210046.pdf
Downloads:
000336256
Publication Details:
Published Paper ID: IJSDR2210046
Registration ID:201981
Published In: Volume 7 Issue 10, October-2022
DOI (Digital Object Identifier):
Page No: 270 - 274
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
Facebook Twitter Instagram LinkedIn