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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Molecular docking studies of lupeol and beta-sitosterol on Immunomodulatory receptors: Research |
| Authors Name: | Ishwari Hemant Sidwadkar , Dr. N. S. Naikwade , Rutuja Nandkumar Mali , Nikhil Dilip More , Dhiraj Jalindhar Pawar |
| Unique Id: | IJSDR2209131 |
| Published In: | Volume 7 Issue 9, September-2022 |
| Abstract: | Abstract- The objective of present work was to study the immunomodulatory potential of lupeol and beta-sitosterol by in silico approach. In silico models involved to study binding affinity of lupeol and beta-sitosterol molecules on immune modified proteins such as Toll like receptor and human tumor necrosis factor-alpha (TNF-α). Docking results showed that the lupeol and beta-sitosterol bioactive molecules were showed immune modulatory activity due to high binding affinity and H bonding interaction with active sites of Toll like receptors and TNF-α respectively as compared to standard immunomodulatory molecule levamisole. Based on docking lupeol and beta-sitosterol were concluded as immunomodulatory potential candidate. |
| Keywords: | immunomodulator.lupeol, beta-sitosterol, Toll like receptors, TNF-α. |
| Cite Article: | "Molecular docking studies of lupeol and beta-sitosterol on Immunomodulatory receptors: Research", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 9, page no.825 - 828, September-2022, Available :http://www.ijsdr.org/papers/IJSDR2209131.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2209131 Registration ID:201874 Published In: Volume 7 Issue 9, September-2022 DOI (Digital Object Identifier): Page No: 825 - 828 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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