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IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

Issue: March 2024

Volume 9 | Issue 3

Impact factor: 8.15

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Paper Title: DEVELOPMENT OF GEL FORMULATIONS OF SYNTHESIZED METHYL SALICYLATE AND ITS EFFECT ON ENZYME INHIBITION ASSAY OF COX-II
Authors Name: ABHILASHA MITTAL , RAJ KUMARI , ISHU YADAV , NAUSHAD AHMED , SOURABH SAINY, ALOK KUMAR
Unique Id: IJSDR2209033
Published In: Volume 7 Issue 9, September-2022
Abstract: Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor. Selective COX-2 inhibitors increase the risk of myocardial infarction and stroke. The actual aim of this research was to synthesize the methyl salicylate and development of a gel formulation with MS and to get a confirmation whether MS having any selective COX II inhibition effect or not. Yield of methyl salicylate was 81% with R.F. value 0.67. The IR spectra of MS was compared with that of the standard peak available in earlier reported articles and identified as MS. But these maximum % inhibition values were similar at the concentration of 250mcg/ml and it was approximately 94%. Although the values of % inhibition at the concentration of 500mcg/ml was little bit lower than the values at 250 and 1000, but it was greater than the PC. From this table it can be concluded that 250mcg/ml will be best among all the COX II enzyme inhibition assay of methyl salicylate. Cox II enzyme inhibition assay of MS Gel is tabulated in Table 5, in which it was mentioned the Log (inhibitor) vs. normalized response and variable slope with 95% Confidence Intervals of IC50 values and it was in the range of 0.1510 to 1.228, but best fit value of IC50 was 0.4307. Goodness of Fit value was statistically evaluated and also calculated in which R2 value was 0.9626, which itself prove that it was most linear and within the acceptable limit. Finally, it can be concluded that MS gel having sufficient COX II enzyme inhibition properties and which may be beneficial as compared to the others having similar to them.
Keywords: Methyl salicylate; COX II enzyme inhibition; FTIR study, IC50
Cite Article: "DEVELOPMENT OF GEL FORMULATIONS OF SYNTHESIZED METHYL SALICYLATE AND ITS EFFECT ON ENZYME INHIBITION ASSAY OF COX-II", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 9, page no.189 - 194, September-2022, Available :http://www.ijsdr.org/papers/IJSDR2209033.pdf
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Publication Details: Published Paper ID: IJSDR2209033
Registration ID:201469
Published In: Volume 7 Issue 9, September-2022
DOI (Digital Object Identifier):
Page No: 189 - 194
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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