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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Paraquat Poisoning And The Salvage Treatment |
| Authors Name: | Dr.Kali Chandra Shekar , Dr. Radhika Pratha , Dr. Rashmita Vakamullu , Dr. Pillajetti Kalasagar , Dr. Kondagorri Sandhya Rani |
| Unique Id: | IJSDR2208106 |
| Published In: | Volume 7 Issue 8, August-2022 |
| Abstract: | The overall purpose of the study is to know the various medications used for the treatment of paraquat poisoning, as there is no perfect treatment. Lomorin, upon adding the anticoagulants to current therapy along with silymarin shows better improvement in patient’s health. Paraquat is a herbicide, widely used in agriculture. The toxicity and severity depends on exposure, dose (in case of suicidal intake), and initiation of the treatment. The emergency cases are considered regardless of COVID (status). The results reported are 38.8% (7 out of 18) of deceased patients. The symptoms are oral ulcers (66%), dysphagia (50%), dyspnea and vomiting (44.4%), icterus (33%). In 61.1% of patients improved condition is noticed ,those who received low molecular weight heparin along with other medications like vitamin C,E, ambroxol, ondansetron, mucaine gel, methylprednisolone, and silymarin. There are many reasons that lead to consumption, like self poisoning, accidental consumption, and psychological issues; mainly the young people are affecting more. Due to lack of proper antidote, the worsening of symptoms occurs and the patients are treated symptomatically. Based on the dose intake, the severity differs. The initial treatment includes gastric lavage, stomach wash but should not induce emesis. As multi organs are affected, proper care must be taken, especially in case of lung tissues, once they are affected and if not treated that leads to ARDS and then lung fibrosis. In case of renal failure, dialysis is preferred; silymarin shows promising results in treating PQ-induced nephrotoxicity. Likewise, corticosteroids and anticoagulants like Lomorin show good results in improving lung functions. Combination therapy is mostly prescribed and regular follow up is needed, even after the recovery of the patients as post treatment complications are more and may even cause death of the patient. |
| Keywords: | paraquat poisoning, lomorin, silymarin, treatment of PQ poisoning. |
| Cite Article: | "Paraquat Poisoning And The Salvage Treatment", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 8, page no.717 - 721, August-2022, Available :http://www.ijsdr.org/papers/IJSDR2208106.pdf |
| Downloads: | 000337078 |
| Publication Details: | Published Paper ID: IJSDR2208106 Registration ID:201320 Published In: Volume 7 Issue 8, August-2022 DOI (Digital Object Identifier): Page No: 717 - 721 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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