|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | IN SILICO ANALYSIS OF SELECTED COMPOUNDS USING PASS, SWISSADME AND MOLINSPIRATION |
| Authors Name: | V.Sundara Prabha , I. Ajitha , S.Beschi Antony Rayan |
| Unique Id: | IJSDR2208075 |
| Published In: | Volume 7 Issue 8, August-2022 |
| Abstract: | The last few decades have seen many pandemic outbreaks of diseases like COVID-19 that need to be fought by a he approach involving modern trends in the drug designing process. The discovery of novel drugs will help us to combat this apart from prevention by vaccination and safety precautions. Building a database of potential candidate drugs will help to develop a drug on a fast track. In this study, five phytochemical compounds (Lycorine, Luteolin, Emodin, Herbacetin and Isobavachalcone) were selected based on the earlier literature available. These compounds were subjected to PASS prediction and the bioactivities of these compounds were screened based on their Pa & Pi values (stimulating activity and inhibitory activity). ADMET studies were done using SwissADME software and the results were discussed. All five compounds were found to be satisfying Lipinski’s rule of five. The Molecular properties analysis such as m Log P, nOHNH, nON, number of violations, and TPSA showed good results as predicted by Molinspiration software. This study brings out the importance of natural products and the use of combinatorial methods in the drug development process. Their physical properties, ADMET analysis and bioactive prediction revealed the importance of the selected compounds to be used to fight against many diseases. uristic |
| Keywords: | SwissADME, PASS, Molinspiration, nOHNH, nON. |
| Cite Article: | "IN SILICO ANALYSIS OF SELECTED COMPOUNDS USING PASS, SWISSADME AND MOLINSPIRATION", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 8, page no.542 - 546, August-2022, Available :http://www.ijsdr.org/papers/IJSDR2208075.pdf |
| Downloads: | 000337078 |
| Publication Details: | Published Paper ID: IJSDR2208075 Registration ID:201282 Published In: Volume 7 Issue 8, August-2022 DOI (Digital Object Identifier): Page No: 542 - 546 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn