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Issue: August 2022

Volume 7 | Issue 8

Impact factor: 8.15

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Paper Title: Thiodicarb Alterations in the Central Nervous System of Albino Mice
Authors Name: P.Jacob Doss , B.PRASANNA , C.BABU , K.VIMALA , B.MONIKA
Unique Id: IJSDR2208003
Published In: Volume 7 Issue 8, August-2022
Abstract: Carbamates are organic compounds derived from carbamic acid. A carbamate group, carbamate ester, and carbamic acids are functional groups that are inter-related structurally and often are interconverted chemically. The carbamate insecticides are widely used as a replacement for its more persistent organochlorine counterparts. The present study is aimed to explore the toxicological effect of a predominantly used carbamate i.e. on different regions of the brain. In the present investigation we have studied the effect of thiodicarb on cholinergic mechanisms in the different regions of brain. For the present study the male mice were exposed to 1/10th LD50 of carbamate via oral gavage (i.e. 0.21 mg/kg body weight). All the experimental animals received the dose on alternate days. After the stipulated period of time different regions of the brain of control and experimental mice were dissected and acetylcholine and acetylcholinesterase activity were measured. The results of the present study indicate a steady decline of acetylcholinesterase (AChE) activity in all the regions of the brain of thiodicarb exposed animals. An increase in acetylcholine (ACh) activity was noticed in all the regions of the experimental mice. We suggest that cholinergic system is seriously affected by the intoxication of thiodicarb and the effect was more in the animals which were exposed to longer duration of time. As Thiodicarb is widely used on crops, they may pose several environmental and health concerns and therefore sufficient caution should be taken while using this compound so that non target animals are not affected.
Keywords: Thiodicarb, ACh, acetylcholinesterase, Albino mice.
Cite Article: "Thiodicarb Alterations in the Central Nervous System of Albino Mice", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 8, page no.14 - 17, August-2022, Available :http://www.ijsdr.org/papers/IJSDR2208003.pdf
Downloads: 000102098
Publication Details: Published Paper ID: IJSDR2208003
Registration ID:201065
Published In: Volume 7 Issue 8, August-2022
DOI (Digital Object Identifier):
Page No: 14 - 17
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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