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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Paper Title:	Thorner`s antagonism: A rare case of see-saw relationship between Myasthenia Gravis and Thyrotoxicosis
Authors Name:	Arnab Chakraborty , Shail Jalan , Suvro Ganguly , Diptendra K Sarkar
Unique Id:	IJSDR2207085
Published In:	Volume 7 Issue 7, July-2022
Abstract:	Thyrotoxicosis & myasthenia gravis (MG) are common diseases but their association is rare. Rennie (1908) was the first to report a case of exopthalmic goitre & myasthenia[1]. In 1939, Melvin W. Thorner reported seven cases of thyrotoxicosis & MG which exhibited a see-saw relationship i.e. mutual antagonism [2]. It was subsequently named Thorner’s antagonism [3]. In most other cases which were reported later, the patients died a myasthenic death following thiouracil therapy[4] or subtotal thyroidectomy[5]. A 38-year old male presented with symptoms of thyrotoxicosis and MG with the former being pre-dominant. After initial treatment with anti-thyroid drugs, the myasthenic component namely muscle weakness & ptosis worsened. He was started on oral Anti-cholinesterase agent, followed by a short course of Plasmapheresis. Thymectomy & total thyroidectomy were done subsequently.
Keywords:	Thorner, Myasthenia, Thyrotoxicosis
Cite Article:	"Thorner`s antagonism: A rare case of see-saw relationship between Myasthenia Gravis and Thyrotoxicosis", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 7, page no.582 - 583, July-2022, Available :http://www.ijsdr.org/papers/IJSDR2207085.pdf
Downloads:	000337077
Publication Details:	Published Paper ID: IJSDR2207085 Registration ID:200919 Published In: Volume 7 Issue 7, July-2022 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.35100 Page No: 582 - 583 Publisher: IJSDR \| www.ijsdr.org ISSN Number: 2455-2631

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