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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Toxicological Evaluation of The Effects of Serial Extracts of Solanum Aculeastrum Seeds on Testosterone Propionate Induced Benign Prostatic Hyperplasia in Male Wistar Rats. |
| Authors Name: | Joseph Anna Ubon , Monday Isaiah Akpanabiatu , Justina Ime Rufus Udotong , Udeme Ededem Okon |
| Unique Id: | IJSDR2207081 |
| Published In: | Volume 7 Issue 7, July-2022 |
| Abstract: | The effect of serial extracts of solanum aculeastrum seeds on liver, kidney and haematological parameters in Wistar rats induced with Benign Prostatic Hyperplasia (BPH) was investigated. Finely ground Solanum aculeastrum seeds (1000 g) were extracted with hexane, chloroform, benzene, ethylacetate and ethanol respectively using serial exhaustive extraction technique. Male Wistar rats weighing 280 ± 20g were injected with 10 mg/kg body weight of Testosterone Propionate through intraperitoneal route for twenty eight days to induce BPH. The animals were divided into eight (8) groups of six (6) rats each. Group 1 (Normal control) was not induced with BPH and served as normal control, group 2 was induced and not treated and served as BPH control, group 3 (Finasteride control) was induced and received standard drug, finasteride while groups 4 (Hexane extract treated group), 5 (Chloroform extract treated group), 6 (Benzene extract treated group), 7 (Ethylacetate extract treated group) and 8 (Ethanol extract treated group) were induced and treated orally with 300 mg/kg body weight of hexane, chloroform, benzene, ethylacetate and ethanol extracts respectively for twenty eight days. The animals were sacrificed and blood collected through cardiac puncture. Biochemical studies were conducted using standard procedures. The results revealed significant (P < 0.05) decreases in serum ALT, AST and ALP activities in all the treated groups compared to the BPH control. The decrease in ALT activity was however not significant compared with the finasteride control whereas the decrease in both AST and ALP activities in all the extracts treated groups were significant compared to the finasteride control. There was no significant (P < 0.05) changes in serum urea concentration but creatinine concentration in the treated groups were significantly reduced when compared to the BPH control and finasteride control. Equally, there were significant increases in RBC, WBC, Hb, LYM and PLT counts in groups 3, 4, 5 and 8 compared to the BPH control. The observed biochemical effects were found to be solvent dependent and compared favourably with the standard drug, finasteride. The results suggest that the serial extracts may be safe for use in medicinal purposes. These findings support the therapeutic use of the fruit berries by the herbalists in treating inflammatory diseases. However, further studies using different doses of each extract should be conducted in order to establish the dose-dependent effects of the extracts. |
| Keywords: | Solanum acculeastrum, BPH, Finasteride, Liver, Kidney, Haematology |
| Cite Article: | "Toxicological Evaluation of The Effects of Serial Extracts of Solanum Aculeastrum Seeds on Testosterone Propionate Induced Benign Prostatic Hyperplasia in Male Wistar Rats.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 7, page no.564 - 573, July-2022, Available :http://www.ijsdr.org/papers/IJSDR2207081.pdf |
| Downloads: | 000337078 |
| Publication Details: | Published Paper ID: IJSDR2207081 Registration ID:200953 Published In: Volume 7 Issue 7, July-2022 DOI (Digital Object Identifier): Page No: 564 - 573 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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