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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Synthesis and evaluation of mutual pro drugs of non-steroidal anti inflammatory drugs with antioxidant |
| Authors Name: | Shabnam saher , Rashmi Sonkusare |
| Unique Id: | IJSDR2207079 |
| Published In: | Volume 7 Issue 7, July-2022 |
| Abstract: | Background: NSAIDs are commonly used alone or in combination with other drugs. These drugs have major side effects like gastrointestinal irritation due to the presence of the carboxylic group in the structure. Therefore, mutual prodrugs of NSAIDs with antioxidants were synthesized toward a pharmacological objective of improving each drug’s efficacy, optimizing delivery, and lowering toxicities. Method: The synthesize compounds were assigned for physical constant determination, λ max, Rf and further subjected for spectral analysis like infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectroscopy. Analgesic activity was performed by using the hot plate method. Carrageenan-induced rat paw oedema method of winter et.al was used for evaluation of an anti-inflammatory activity. Invitro and invivo bioavailability studies were carried out for synthesized products. Results: The structures of 17a,17b, 19a, 19b, 21a, 21b were confirmed by IR, NMR and Mass spectral data. The synthesized mutual prodrugs (17a-b), (19a-b) and (21a-b) showed significant analgesic and anti-inflammatory activity as compared to standard compounds. The results showed that the free drug IBU, MEF and INDO and their mutual prodrugs (17a-b), (19a-b) and (21a-b) gives plasma concentration increase sharply within 1 hr after administration, but in free drug decrease rapidly with time and in mutual prodrugs plasma concentration was maintained for a long time. Conclusion: On the basis of the above observations, it is concluded that these mutual prodrugs conjugates can be successfully applied to attain the goal of minimizing gastrointestinal toxicity without loss of the desired anti-inflammatory and analgesic activity of the drug. The pharmacokinetic studies showed greater bioavailability as compared to parent’s compounds. |
| Keywords: | NSAIDs; Mutual prodrugs; Antioxidants; Spectroscopy; Anti-inflammatory; Bioavailability |
| Cite Article: | "Synthesis and evaluation of mutual pro drugs of non-steroidal anti inflammatory drugs with antioxidant", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 7, page no.551 - 557, July-2022, Available :http://www.ijsdr.org/papers/IJSDR2207079.pdf |
| Downloads: | 000337067 |
| Publication Details: | Published Paper ID: IJSDR2207079 Registration ID:201000 Published In: Volume 7 Issue 7, July-2022 DOI (Digital Object Identifier): Page No: 551 - 557 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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