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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A comparative analysis of arterial thrombotic events in post-COVID syndrome and its correlation with a hypercoagulable state |
| Authors Name: | Dr. Sudhir Bhandari , Dr. Shiven Bhandari , Dr. Govind Rankawat , Dr. Ajeet Singh , dr. Anurag Lohmror |
| Unique Id: | IJSDR2207058 |
| Published In: | Volume 7 Issue 7, July-2022 |
| Abstract: | Background: Coronavirus disease 2019 can be complicated by post-COVID thrombotic events and need hospitalization. We aimed to discuss the presence of post-COVID thrombotic events and its possible causality in vulnerable patients of COVID-19 to set up an effective preventive and therapeutic strategy for this fatal complication. Methods: This prospective observational case-control study included a total of 150 admitted patients with COVID-19 after exclusion of chronic medical illness. All patients were closely observed for their demography, clinical profile, disease severity, duration of hospitalization, post-COVID symptoms, and inflammatory markers. All collected data were tabulated, compiled, and analyzed to establish the possible causality of post-COVID thrombotic events. Results: Among the study sample 20 patients developed post-COVID thrombotic events as cases and the remaining 130 had without thrombotic events as a control group. Patients with post-COVID thrombotic events had longer duration of hospitalization (12.6 v/s 9.4 days), higher prevalence of nonspecific post-COVID symptoms (90% v/s 66.15%), and had raised inflammatory markers (CRP 14.04 v/s 10.73; D-dimer 1012.5 v/s 516.4 µg/Ml; IL-6 32.88 v/s 15.07) as compared to control group of without thrombotic events with p-value < 0.05. In our study thrombotic events developed on an average of 10th week from the first positive serology or symptoms onset with a mean time duration of thrombotic events was found to be 66.05 days. Conclusion: Post-COVID thrombotic events after COVID infection can be precipitated by a longer duration of hospitalization with a persistent higher inflammatory state and hypercoagulable state. Incidence of thrombotic events is directly proportional to the severity of the disease. |
| Keywords: | COVID-19, Hypercoagulable state, Inflammatory markers, Post-COVID thrombotic events |
| Cite Article: | "A comparative analysis of arterial thrombotic events in post-COVID syndrome and its correlation with a hypercoagulable state", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 7, page no.419 - 425, July-2022, Available :http://www.ijsdr.org/papers/IJSDR2207058.pdf |
| Downloads: | 000337061 |
| Publication Details: | Published Paper ID: IJSDR2207058 Registration ID:200934 Published In: Volume 7 Issue 7, July-2022 DOI (Digital Object Identifier): Page No: 419 - 425 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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