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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Simultaneous Estimation of Perindropil and Amlodipine with possible degradants in fixed dose pharmaceutical formulation by UV Spectroscopic method. |
| Authors Name: | D. Prashanthi , Dr. Ramesh B , Manish |
| Unique Id: | IJSDR2203043 |
| Published In: | Volume 7 Issue 3, March-2022 |
| Abstract: | A novel, simple, precise and reproducible UV stability indicating spectroscopic method has been developed and validated according to ICH Q2R1 guidelines for the simultaneous estimation of Perindropil and Amlodipine used as cardiovascular drugs in fixed dose pharmaceutical formulations. Pure drug samples were dissolved in Methanol and found to have absorbance maxima at 209 nm and 229 nm for Perindropil and Amlodipine respectively. Beer’s law was obeyed over concentration ranges of 8-40 μg/ml for Perindropil and 10-50 μg/ml for Amlodipine in this method. Simultaneous calibration of both drugs in Methanol shows that λmax of one drug does not interfere on the λmax of other drug. The results of analysis have been validated statistically as per ICH guidelines and recovery studies confirmed the accuracy of the proposed methods. The method showed good reproducibility and recovery with % RSD <2. Stability indicating studies were done by subjecting to acid and alkali hydrolysis, oxidation, thermolysis and photolysis. Hence, this proposed method was found to be rapid, specific, precise, accurate and can be successfully applied for the routine analysis of Perindropil and Amlodipine in fixed dose pharmaceutical formulations. |
| Keywords: | UV Spectroscopic method, Validation, Beer’s law, Perindropil, Amlodipine. |
| Cite Article: | "Simultaneous Estimation of Perindropil and Amlodipine with possible degradants in fixed dose pharmaceutical formulation by UV Spectroscopic method.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 3, page no.299 - 305, March-2022, Available :http://www.ijsdr.org/papers/IJSDR2203043.pdf |
| Downloads: | 000337071 |
| Publication Details: | Published Paper ID: IJSDR2203043 Registration ID:200157 Published In: Volume 7 Issue 3, March-2022 DOI (Digital Object Identifier): Page No: 299 - 305 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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