Welcome to IJSDR UGC CARE norms ugc approved journal norms IJRTI Research Journal | ISSN : 2455-2631
IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.15 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)

Issue: August 2022

Volume 7 | Issue 8

Impact factor: 8.15

Click Here For more Info

Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter

Copyright Infringement Claims
Indexing Partner
Published Paper Details
Paper Title: Evaluation of Anti-diabetic effect of Jasminum polyanthum hydroalcoholic extract on streptozotocin induced diabetic rats
Authors Name: Saraswathi R , Dr.P.Muralidaran
Unique Id: IJSDR2203038
Published In: Volume 7 Issue 3, April-2022
Abstract: Background: Currently, there is a demand for new antidiabetic drugs from natural sources and diabetes mellitus disease is global epidemic now. The flower of Jasminum polyanthum has been used in various traditional system medicine for its valuable therapeutic uses. Aim: The aim of the present study is to evaluate the anti-diabetic effect of the Jasminum polyanthum hydroalcoholic extract on streptozotocin induced diabetic rats. Material and method:The flower of Jasminum polyanthum(JP) was collected from Villupurm, Tamilnadu, and dried in shade.The dried flower was powdered in a blender and it was extracted using soxhlet,hydroalcoholic solvent was used(80:20). Animals are divided into five group each contain six animals. Streptozotocin (40mg/kg) dose is used for inducing diabetes in wistar male rats. Treatment with Glibenclamide and JP hydroalcoholic extract (200mg and 400mg/kg) was for 21 days body weight , food intake,water intake and blood glucose level was observed. The blood concentrations of TC, TG, LDL, VLDL and HDL was done . Antioxidant activity of Superoxide dismutase (SOD), glutathione reductase (GR), Catalase(CAT) was carried out using pancreatic supernatant. Histopathology examination was done on pancreas. Results: The extract of Jasminum polyanthum and standard shows normal intake of food and water but body weight was slightly increased. There was a significant (p < 0.001 and ns) decrease in blood glucose level at doses of 200 mg/kg and 400mg/kg when compared with STD group. The observation was carried out on 0th, 3rd, 7th ,14th ,21st and 28th day . On 28th day the animals were sacrificed and pancreas were homogenized, supernatant was tested for antioxidant Superoxide dismutase (SOD), glutathione reductase (GR), Catalase(CAT) in which significantly (p<0.001) increased. Lipid profile showed significant increase in HDL cholesterol and significant decrease (p < 0.01) in TC, VLDL, LDL, TG were observed.Histopathology examination confirmed the restoration of β-cells of the islets of Langerhans and regeneration of β-cells were found to be increased . Conclusion: The present study shows that the hydroalcoholic flower extract of Jasminum polyanthum has antidiabetic, and antioxidant activity . Keywords: Jasminum polyanthum, Streptozotocin, Glibenclamide, Anti diabetic activity, Anti-oxidants
Keywords: Jasminum polyanthum, Streptozotocin, Glibenclamide, Anti diabetic activity, Anti-oxidants
Cite Article: "Evaluation of Anti-diabetic effect of Jasminum polyanthum hydroalcoholic extract on streptozotocin induced diabetic rats", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 3, page no.268 - 272, April-2022, Available :http://www.ijsdr.org/papers/IJSDR2203038.pdf
Downloads: 000101745
Publication Details: Published Paper ID: IJSDR2203038
Registration ID:200169
Published In: Volume 7 Issue 3, April-2022
DOI (Digital Object Identifier):
Page No: 268 - 272
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

Click Here to Download This Article

Article Preview

Click here for Article Preview







Major Indexing from www.ijsdr.org
Google Scholar ResearcherID Thomson Reuters Mendeley : reference manager Academia.edu
arXiv.org : cornell university library Research Gate CiteSeerX DOAJ : Directory of Open Access Journals
DRJI Index Copernicus International Scribd DocStoc

Track Paper
Important Links
Conference Proposal
ISSN
DOI (A digital object identifier)


Providing A digital object identifier by DOI
How to GET DOI and Hard Copy Related
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Creative Commons License
This material is Open Knowledge
This material is Open Data
This material is Open Content
Social Media
IJSDR

Indexing Partner