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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Issue: August 2022

Volume 7 | Issue 8

Impact factor: 8.15

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Paper Title: Bystander Activation: A Germane Mechanism in the Pathogenesis of Periodontitis
Authors Name: Dr. B. Ramya Bharathi , Dr. C. Srikanth , Dr. M. Navya , Dr. P. Usha
Unique Id: IJSDR2203018
Published In: Volume 7 Issue 3, March-2022
Abstract: It is characterized by autoreactive B and T cells that undergo activation in an antigen-independent manner. Activation of such includes inflammatory milieu, co-signaling ligands and interaction with neighboring cells in periodontal diseases. The evasion of periodontal pathogens in the host causes immune dysregulation and further activates the enzymes that could directly or indirectly trigger the innate immune cells, e.g. pattern recognition receptors. The significant variations occurring in the infected cell, as well as an adjacent uninfected cell to produce inflammatory mediators through autocrine or paracrine signaling cascade, is called Bystander activation. This review aims to summarize the host and oral microbiota changes involved in the physio-pathogenesis of periodontitis that has been described as bystander activation which is contributing to overall responses causing disease.
Keywords: Bystander activation, Autoimmunity, Innate immunity.
Cite Article: "Bystander Activation: A Germane Mechanism in the Pathogenesis of Periodontitis", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 3, page no.127 - 131, March-2022, Available :http://www.ijsdr.org/papers/IJSDR2203018.pdf
Downloads: 000101745
Publication Details: Published Paper ID: IJSDR2203018
Registration ID:200147
Published In: Volume 7 Issue 3, March-2022
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.29849
Page No: 127 - 131
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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