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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Volume 7 | Issue 6

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Paper Title: Toxicological Evaluation of Unlined Landfill Leachate on Biochemical Responses in the Tissues of Rattus novergicus
Authors Name: Onojeghuo, E. , Adeyemi, O. , Fajinmi, V. , Isukuru, E. J. , Akpejeluh, P.
Unique Id: IJSDR2201060
Published In: Volume 7 Issue 1, January-2022
Abstract: Effect of unlined leachate on biochemical responses in different tissues of Rattus novergicus was evaluated by toxicological bioassay, using different sub-lethal concentrations (5, 10, 15 and 20% v/v) for 28-days duration. Results of the present study indicate that SOD and CAT in the liver were significantly (p<0.05) lower in all experimented groups except Group 1, while in the kidney, SOD and CAT were significantly (p<0.05) higher in all experimented groups except Group 1 when compared to control group. SOD in the liver and kidney of rats in Group 1 was 215±0.51 and 160±0.34, while CAT was 0.23±4.38 and 0.23±3.34 respectively. Elevated Malondialdehyde (MDA) was an evidence of lipid peroxidation where the MDA values in the liver and kidney of rats in all experimented groups were significantly higher than control group (p<0.05). Also, Leachate constituents interfere with protein and carbohydrate metabolisms in the liver by loss of Alanine aminotransferase (ALT) activity subject liver lipids to peroxidation as detected by Ascorbic acid (ASB) activity leading to loss of membrane integrity. ALT and ASB values in the liver were significantly lower in all experimented groups when compared to control group (p<0.05). In the kidney, ASB was significantly (p<0.05) lower in all experimented groups except Group 1 when compared to control group. ASB of liver and kidney of experimented rats in Group 3 was 1.26±0.01 and 1.85±0.02 while control was 1.23±0.01 and 1.27±0.01 respectively. These findings show the potentials of unlined landfill Leachates to induce tissue dysfunction.
Keywords: Unlined landfill leachate, SOD, CAT, MDA, ALT, ASB, Toxicity
Cite Article: "Toxicological Evaluation of Unlined Landfill Leachate on Biochemical Responses in the Tissues of Rattus novergicus", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 1, page no.386 - 392, January-2022, Available :http://www.ijsdr.org/papers/IJSDR2201060.pdf
Downloads: 00096793
Publication Details: Published Paper ID: IJSDR2201060
Registration ID:193909
Published In: Volume 7 Issue 1, January-2022
DOI (Digital Object Identifier):
Page No: 386 - 392
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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