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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Issue: June 2022

Volume 7 | Issue 6

Impact factor: 8.15

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Paper Title: Expression Of Toll-Like Receptors (TLR2 AND TLR4) In The Wistar Dental Pulp After Being Given GIC (Glass Ionomer Cement) With Addition Of Gouramy Fish Scales
Authors Name: I Dewa Ayu Ratna Dewanti , I Dewa Ayu Susilawati , Erawati Wulandari , Agus Sumono , Sunlip Wibisono
Unique Id: IJSDR2201030
Published In: Volume 7 Issue 1, January-2022
Abstract: Gouramy fish scales have a similar composition with the teeth and alveolar bones. Material must be able to recognize microorganisms via TLR receptors. TLR2 and TLR4 have outstanding abilities in identifying a variety of pathogenic ligands. Aim. Analyzing the expression of TLR2 and TLR4 on dental pulp after being given GIC with addition of Gouramy fish scales. 24 male Wistar rats were grouped into: K (rats made holes in their teeth), P1 (rats made holes in their teeth + GIC, P2 (rats made holes in their teeth + GIC + Gouramy fish scales). Day 3, 7 were made of tooth for TLR2 and TLR4 analysis using immunohistochemical methods. Cells were counted under a light microscope with magnification of 1000X and 400X. The data obtained were analyzed using ANOVA followed by LSD test. The result showed that the scales of Gouramy and GIC were able to reduce the expression of TLR2 and TLR4, caused by antibacterial content in both GIC and Gouramy fish scales. Gouramy fish scales also contain bioactive components that can act as anti-inflammatory. Conclusion. The addition of Gouramy fish scales to GIC decreased the expression of TLR2 and TLR4 in the dental pulp of Wistar rats.
Keywords: anti-inflammatory; bioactive components; immunohistochemistry; immunomodulators; receptor; restorative
Cite Article: "Expression Of Toll-Like Receptors (TLR2 AND TLR4) In The Wistar Dental Pulp After Being Given GIC (Glass Ionomer Cement) With Addition Of Gouramy Fish Scales", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 1, page no.210 - 215, January-2022, Available :http://www.ijsdr.org/papers/IJSDR2201030.pdf
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Publication Details: Published Paper ID: IJSDR2201030
Registration ID:193793
Published In: Volume 7 Issue 1, January-2022
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Page No: 210 - 215
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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