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IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

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Impact factor: 8.15

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Paper Title: FACTORS AFFECTING RAPAMYCIN (SIROLIMUS) PRODUCTION - A REVIEW
Authors Name: Umesh Luthra , Abhishek Tomar
Unique Id: IJSDR2112022
Published In: Volume 6 Issue 12, December-2021
Abstract: Immunosuppressants are gaining in popularity in recent years as a result of their important contribution to the medical and pharma industries and huge demand in the global market. Rapamycin (sirolimus) is an immunosuppressive drug that also has antitumor antifungal, anti-aging, and neuroprotective properties. Many strains of Streptomyces hygroscopicus use a submerged fermentation approach to produce rapamycin. Albeit the wild strain's production capacity is extremely low, therefore to enhance the production of rapamycin a thorough investigation of media optimization, bioprocess engineering parameters is required to address this issue. This review emphasizes the remarkable approaches of media optimization, statistical approach, and studies on gene level to scale up the titer of rapamycin.
Keywords: Sirolimus, Rapamycin, Streptomyces hygroscopicus., Immunosuppressant, Transplantation, Fermentation
Cite Article: "FACTORS AFFECTING RAPAMYCIN (SIROLIMUS) PRODUCTION - A REVIEW", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 12, page no.156 - 160, December-2021, Available :http://www.ijsdr.org/papers/IJSDR2112022.pdf
Downloads: 000336256
Publication Details: Published Paper ID: IJSDR2112022
Registration ID:193766
Published In: Volume 6 Issue 12, December-2021
DOI (Digital Object Identifier):
Page No: 156 - 160
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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