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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A BRIEF REVIEW ON PRURITUS IN CHOLESTASIS |
| Authors Name: | Nishita Prajapati , Dhruvi Patel , Pinki Purohit , Anali Patel , Nikita Champaneri |
| Unique Id: | IJSDR2111007 |
| Published In: | Volume 6 Issue 11, November-2021 |
| Abstract: | Pruritus is an enfeeble symptom in those patients having cholestatic liver disease, including primary sclerosing cholangitis, primary biliary cirrhosis, and intrahepatic cholestasis of pregnancy. Various factors are involved in the occurrence of pruritus, such as its appearance varies from patient to patient, it will be intermittent or persistent, generalized or localized to specific parts of the body like toes and palm. Based on the etiology of cholestasis, antihistamines show unresponsive effects in patients with Cholestasis pruritus and can lead to sleep deprivation, lack of attention, and prurigo nodularis due to scratching. In severe cases of cholestasis pruritus, suicidal ideations may develop, and pruritus becomes the primary indication for liver transplantation. Cholestasis-associated pruritus also shows a diurnal rhythm having a peak intensity at late evening and an early night. The peripheral and central neurological systems have been linked to the mechanism of pruritus, leading to the development of several treatment alternatives. Most of these treatments have little evidence of efficacy at this time, indicating that more research is needed. The following review scrutinizes the current literature on epidemiology, pathogenesis, and treatment of Pruritus in Cholestasis. |
| Keywords: | Pruritus, Cholestasis, sclerosing cholangitis, prurigo nodularis |
| Cite Article: | "A BRIEF REVIEW ON PRURITUS IN CHOLESTASIS", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 11, page no.21 - 26, November-2021, Available :http://www.ijsdr.org/papers/IJSDR2111007.pdf |
| Downloads: | 000337071 |
| Publication Details: | Published Paper ID: IJSDR2111007 Registration ID:193699 Published In: Volume 6 Issue 11, November-2021 DOI (Digital Object Identifier): Page No: 21 - 26 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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