INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
THE EFFECT OF CAPMATINIB FOR THE TREATMENT OF MET AMPLIFIED NON SMALL CELL LUNG CANCER
Authors Name:
Dr. R Dinesh Kumar
, Christina Ponnachen , Bivishya R , Jormy John
Unique Id:
IJSDR2108018
Published In:
Volume 6 Issue 8, August-2021
Abstract:
ABSTRACT PRINCIPLE: To assess the effect of capmatinib, a potent selective inhibitor of MET receptor among patients with non-small cell cancer (NSCLC) with MET dysregulation Among patients with non–small-cell lung cancer (NSCLC), MET amplifications occur in 1 to 6%. METHODS: A multiple-cohort, phase 2 study was conducted evaluating capmatinib in patients with MET-dysregulated advanced NSCLC. Patients were assigned to cohorts on the basis of previous lines of therapy and MET status (MET exon 14 skipping mutation or MET amplification according to gene copy number in tumour tissue). Patients received capmatinib (400-mg tablet) twice daily. The primary goal was to find the safety and efficacy of the drug, also to evaluate antitumour activity. RESULTS: The total date was collected and among patients with NSCLC with MET dysregulation, overall response showed improved survival within these patients. The most frequently reported adverse events were peripheral edema (in 51%) and nausea (in 45%); these events were mostly of grade 1 or 2. CONCLUSION: From the collected, we have concluded that capmatinib showed substantial antitumour activity in NSCLC with MET dysregulation. Low-grade peripheral edema and nausea were the main toxic effect.
Keywords:
Capmatinib, Non small cell lung cancer, MET amplication.
Cite Article:
"THE EFFECT OF CAPMATINIB FOR THE TREATMENT OF MET AMPLIFIED NON SMALL CELL LUNG CANCER", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 8, page no.106 - 111, August-2021, Available :http://www.ijsdr.org/papers/IJSDR2108018.pdf
Downloads:
000336256
Publication Details:
Published Paper ID: IJSDR2108018
Registration ID:193598
Published In: Volume 6 Issue 8, August-2021
DOI (Digital Object Identifier):
Page No: 106 - 111
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
Facebook Twitter Instagram LinkedIn