THE EFFECT OF CAPMATINIB FOR THE TREATMENT OF MET AMPLIFIED NON SMALL CELL LUNG CANCER
Dr. R Dinesh Kumar
, Christina Ponnachen , Bivishya R , Jormy John
Capmatinib, Non small cell lung cancer, MET amplication.
ABSTRACT PRINCIPLE: To assess the effect of capmatinib, a potent selective inhibitor of MET receptor among patients with non-small cell cancer (NSCLC) with MET dysregulation Among patients with non–small-cell lung cancer (NSCLC), MET amplifications occur in 1 to 6%. METHODS: A multiple-cohort, phase 2 study was conducted evaluating capmatinib in patients with MET-dysregulated advanced NSCLC. Patients were assigned to cohorts on the basis of previous lines of therapy and MET status (MET exon 14 skipping mutation or MET amplification according to gene copy number in tumour tissue). Patients received capmatinib (400-mg tablet) twice daily. The primary goal was to find the safety and efficacy of the drug, also to evaluate antitumour activity. RESULTS: The total date was collected and among patients with NSCLC with MET dysregulation, overall response showed improved survival within these patients. The most frequently reported adverse events were peripheral edema (in 51%) and nausea (in 45%); these events were mostly of grade 1 or 2. CONCLUSION: From the collected, we have concluded that capmatinib showed substantial antitumour activity in NSCLC with MET dysregulation. Low-grade peripheral edema and nausea were the main toxic effect.
"THE EFFECT OF CAPMATINIB FOR THE TREATMENT OF MET AMPLIFIED NON SMALL CELL LUNG CANCER", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.6, Issue 8, page no.106 - 111, August-2021, Available :https://ijsdr.org/papers/IJSDR2108018.pdf
Volume 6
Issue 8,
August-2021
Pages : 106 - 111
Paper Reg. ID: IJSDR_193598
Published Paper Id: IJSDR2108018
Downloads: 000347190
Research Area: Pharmacy
Country: erode, tamil nadu, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
