A Clinical approach to the adverse drug reaction in the management of multidrug-resistant tuberculosis

Dr.R.DINESH KUMAR , PIONEER E , ASMA ABDURAHMAN , SARFARAAS AHAMATH S

Tuberculosis, Multidrug- resistant tuberculosis, Anti-tubercular therapy, Adverse drug reactions.

AIM AND OBJECTIVE: Multidrug Resistant Tuberculosis is considered to be a worldwide problem with notoriously difficult and challenging treatment. Antituberculosis multidrug regimens have been associated with increased incidence of adverse drug reactions. This study have been framed to determine the incidence and associated factors of ADRs due to antituberculosis treatment. METHOD: A search approach was used, that included the use of major electronic databases for instance PubMed, EMBASE, MEDLINE, library catalogues, and Google as well as a manual search of International journal of Tuberculosis and lung disease. RESULT: Twenty one articles including one systemic reviews have been identified and the overall prevalence of ADRs associated with MDR-TB are estimated. The occurrence of ADRs may be influenced by multiple factors and may range from mild gastrointestinal disturbances to serious hepatotoxicity, ototoxicity, nephrotoxicity peripheral neuropathy, cutaneous ADRs etc. Agents responsible for these adverse effects were Kanamycin, Cycloserine, Ethionamide,and Pyrazinamide. CONCLUSION: Early recognition by active surveillance/reporting ADRs and appropriate management of these ADRs might improve adherence and treatment success and is a remarkable relevance to prevent emergence threat of global MDR-TB.

Published Paper   E-Certificate

"A Clinical approach to the adverse drug reaction in the management of multidrug-resistant tuberculosis ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.6, Issue 8, page no.98 - 105, August-2021, Available :https://ijsdr.org/papers/IJSDR2108017.pdf

Volume 6 Issue 8, August-2021

Pages : 98 - 105

Paper Reg. ID: IJSDR_193595

Published Paper Id: IJSDR2108017

Downloads: 000347210

Research Area: Pharmacy

Country: Erode, Tamil Nadu, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2108017

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2108017

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition