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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A Clinical approach to the adverse drug reaction in the management of multidrug-resistant tuberculosis |
| Authors Name: | Dr.R.DINESH KUMAR , PIONEER E , ASMA ABDURAHMAN , SARFARAAS AHAMATH S |
| Unique Id: | IJSDR2108017 |
| Published In: | Volume 6 Issue 8, August-2021 |
| Abstract: | AIM AND OBJECTIVE: Multidrug Resistant Tuberculosis is considered to be a worldwide problem with notoriously difficult and challenging treatment. Antituberculosis multidrug regimens have been associated with increased incidence of adverse drug reactions. This study have been framed to determine the incidence and associated factors of ADRs due to antituberculosis treatment. METHOD: A search approach was used, that included the use of major electronic databases for instance PubMed, EMBASE, MEDLINE, library catalogues, and Google as well as a manual search of International journal of Tuberculosis and lung disease. RESULT: Twenty one articles including one systemic reviews have been identified and the overall prevalence of ADRs associated with MDR-TB are estimated. The occurrence of ADRs may be influenced by multiple factors and may range from mild gastrointestinal disturbances to serious hepatotoxicity, ototoxicity, nephrotoxicity peripheral neuropathy, cutaneous ADRs etc. Agents responsible for these adverse effects were Kanamycin, Cycloserine, Ethionamide,and Pyrazinamide. CONCLUSION: Early recognition by active surveillance/reporting ADRs and appropriate management of these ADRs might improve adherence and treatment success and is a remarkable relevance to prevent emergence threat of global MDR-TB. |
| Keywords: | Tuberculosis, Multidrug- resistant tuberculosis, Anti-tubercular therapy, Adverse drug reactions. |
| Cite Article: | "A Clinical approach to the adverse drug reaction in the management of multidrug-resistant tuberculosis ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 8, page no.98 - 105, August-2021, Available :http://www.ijsdr.org/papers/IJSDR2108017.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2108017 Registration ID:193595 Published In: Volume 6 Issue 8, August-2021 DOI (Digital Object Identifier): Page No: 98 - 105 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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